Low circulating IGF-I is associated with increased fracture risk. Conditional depletion of IGF-I produced in osteoblasts or osteocytes inhibits the bone anabolic effect of mechanical loading. Here, we determined the role of endocrine IGF-I for the osteogenic response to mechanical loading in young adult and old female mice with adult, liver-specific IGF-I inactivation (LI-IGF-I(-/-) mice, serum...

Partially demineralized (DM) bone is of interest due to its promising osteointegrative properties for advanced bone grafts. Structural features of partially DM (35 vol.%, 45 vol.% and 55 vol.% reduction), and untreated cortical bone samples were studied by scanning electron microscopy. Mechanical properties were investigated by compression testing in three anatomical directions at different sta...

INTRODUCTION: Impaction grafting is a common procedure in the reconstruction of cavity defects. Concerns regarding sterility of the graft material may require gamma irradiation prior to implantation. The grafts’ mechanical properties play an important role in surgical handling and in-vivo response. Gamma irradiation adversely affects the mechanical properties in a dose dependent fashion in cort...

The application of porous bio-nanocomposites polymer has greatly increased in the treatment of boneabnormalities and bone fracture. Therefore, predicting the mechanical properties of these bio-nanocompositesare very important prior to their fabrication. Investigation of mechanical properties like (elasticmodulus and hardness) is very costly and time-consuming in experimental t...

Bones are living organs with the ability to adapt themselves to their mechanical demands. This phenomenon is of great importance in endoprosthetics. Due to a total hip joint replacement for example the bone is stressed in a non–physiological manner which causes bone remodeling. Therefore, the durability of the artificial device depends strongly on the prosthesis design. This biomechanical behav...

introduction: systemic application of capsaicin to neonatel rodents depletes their primary afferent c-fibers and also results in a wide variety of changes observable in adulthood. the manual methods used for stimulation of vibrissa provide limited information on response properties of barrel cortical neurons. in this study the effect of c-fiber depletion induced by neonatal capsaicin (cap) trea...

 longevity of osseointegrated implants are intensely influenced by biomechanical factors. Control of these factors prevents mechanical complications, which include fracture of screws, components, or materials veneering the framework. In this study, the impact of length and threads pitch of dental implants on the stress distribution and maximum Von Mises stress in implant-abutment complex and ja...

OBJECTIVE Rosiglitazone (RSG) is an insulin-sensitizing drug used to treat type 2 diabetes mellitus. The A Diabetes Outcome Progression Trial (ADOPT) shows that women taking RSG experienced more fractures than patients taking other type 2 diabetes drugs. These were not osteoporotic vertebral fractures but, rather, occurred in the limbs. The purpose of this study was to investigate how RSG treat...

4.1 Acoustic Microscopy Theory, Techniques, and Specimen Preparation The Physical Interaction between Ultrasound and Solid Media • A Historical Perspective of the Study of Bone with Acoustic Microscopy • Specimen Preparation • The Acoustic Microscope 4.2 Acoustic Studies of Cortical Bone Material Properties Low Frequency • High Frequency 4.3 Acoustic Microscopy and Biomaterials Analysis Acousti...

Chronic kidney disease (CKD), which leads tocortical bone loss and increasedporosity,increases therisk of fracture. Animal models have confirmed that these changes compromise whole bone mechanical properties. Estimates from whole bone testing suggest that material properties are negatively affected, though tissue-level assessmentshavenot been conducted. Therefore, the goal of the present study ...