Following acute arsenic ingestion, a 35 year old woman experienced multiple organ failure, including renal and respiratory insufficiency, toxic hepatitis, peripheral neuropathy, and encephalopathy. In addition, she developed an anemia; the bone marrow showed a striking dyserythropoiesis with megaloblastic features. Her recovery was heralded by normalization of the bone marrow morphology, follow...

Normal human peripheral blood lymphocytes cultured with phytohemagglutinin in folate-free RPMI 1 640 medium supplemented with normal human serum exhibit megaloblastic maturation. These changes are accompanied by a decrease in intracellular folate content. and when compared to folate-replete cells. reveal increased 3H-thymidine incorporation into DNA together with a decreased inhibitory effect o...

Vitamin B12 and Folate play akey role inDNA synthesis in the dividing cells of the body. Deficiency of one or both of these results in reduced synthesis of DNA1,2. This leads to megaloblastic anaemia characterised by a characteristic pattern of morphological and functional abnormalities in peripheral blood and bone marrow cells. Interpretation of the serum levels of vitamin B,2 and Folate are d...

Thiamine-responsive megaloblastic anemia (TRMA) is a clinical triad characterized by megaloblastic anemia, non-autoimmune diabetes mellitus, and sensory-neural hearing loss. Mutations in the thiamine transporter gene, solute carrier family 19, member 2 (SLC19A2), have been associated with TRMA. Three pediatric patients from a large consanguineous Iranian family with hyperglycemia, anemia, and h...

BACKGROUND Thiamine-responsive megaloblastic anemia syndrome (TRMA), also known as Rogers syndrome, is characterized by megaloblastic anemia, sensorineural hearing loss, and diabetes mellitus. Disturbances of the thiamine transport into the cells results from homozygous or compound heterozygous mutations in the SLC19A2 gene. CASE PRESENTATION We report a girl which presented with sensorineura...

Megaloblastic erythropoiesis is known to occur in patients with chronic hemolytic anaemia. It has been described in association with sickle cell anemia (Oliner and Heller 1959 ), thalassaemia (Robinson and Watson 1963 ), congenital spherocytosis ( Delamore et al. 1961), and acquired hemolytic anemia ( Forshaw and Harwood 1963). In a survey of the literature up to 1962, Robinson and Watson (1963...

The present study describes a case of an elderly patient that was hospitalized secondary to hypotension and delirium. Physical examination at admission revealed bilateral positive Babinski's sign. Laboratory examination revealed severe anemia. Bone marrow examination showed megaloblastic changes of the granulocyte and erythroid series, as well as other dyshaematopoiesis. The conditions of the p...

Introduction THE simultaneous occurrence in the bone marrow of megaloblasts and ring-sideroblasts may result from a variety of causes. In a series of seventy patients with sideroblastic anaemia, MacGibbon and Mollin (1965) observed megaloblastic change in 544O of cases of primary sideroblastic anaemia, and in 74YO of cases of secondary sideroblastic anaemia. The megaloblastic change was attribu...

OBJECTIVE The objective was to study megaloblastic anemia as a cause of pyrexia of unknown origin (PUO). MATERIALS AND METHODS We conducted a study on 15 patients of megaloblastic anemia associated with fever, attending our hospital clinics over a period of 6 months. RESULTS While 11 patients had symptoms suggesting foci of infection and responded well to intravenous antibiotics, 4 patients...