Background: Clopidogrel is a prodrug that converts in the liver to an active thiol metabolite, which irreversibly inhibits the platelet P2Y12 adenosine diphosphate receptor. It seems that methadone as CYP2C19 inhibitor affects ticlopidine activity in vivo. This study aimed to test the ability of methadone in changing ticlopidine pharmacokinetics. Methods: We conducted a case–control st...

Background: Studies have shown that methadone maintenance treatment (MMT) is effective in improving the client’s quality of life and physical health. This study aimed to describe the nature and structure of drug dependents' experiences and the physical effects of MMT Methods: The present study is a qualitative and a phenomenology study on 32 clients referred to methadone clinics in the city of ...

Hyperalgesia is a common clinical phenomenon among opioid dependent patients on methadone maintenance therapy (MMT) and it may be associated with undertreated pain and/or therapeutic failure. This study aimed to investigate association between serum methadone concentration (SMC) and cold pressor pain responses. Cold pressor pain responses in 147 opioid dependent patients on MMT were assessed us...

background: methadone is considered a long-acting opioid agonist which is widely used in the treatment of drug addiction. it is believed that opioids can cause erectile dysfunction (ed) by inhibiting gonadotropin and testosterone release. this study is aimed at defining the possible effects of conservative treatment with methadone on erectile dysfunction in the addicts. methods: a total of 382 ...

OBJECTIVE To evaluate the impact of methadone dose on post-release retention in treatment among HIV-infected prisoners initiating methadone maintenance treatment (MMT) within prison. METHODS Thirty HIV-infected prisoners meeting DSM-IV pre-incarceration criteria for opioid dependence were enrolled in a prison-based, pre-release MMT program in Klang Valley, Malaysia; 3 died before release from...

Background: Substance abuse treatment is challenging in pregnancy, and methadone maintenance therapy (MMT) a therapeutic choice. Methadone can cross the placenta poorly secreted breast milk. Given these inconsistent findings of effect on neonatal outcomes, this study was done to investigate results neonates mothers treated with Mashhad. Methods: In retrospective cohort study, referring two acad...

Background and aims: Sexual dysfunction is a common complaint among drug abusers in the treatment with Methadone and Buprenorphine. The aim of this study was to assess sexual dysfunction in patients undergoing Methadone or Buprenorphine for maintenance therapy. Methods: This research was a cross-sectional study. A 3-parts questionnaire (demographic questi...

BACKGROUND Clopidogrel is a prodrug that converts in the liver to an active thiol metabolite, which irreversibly inhibits the platelet P2Y12 adenosine diphosphate receptor. It seems that methadone as CYP2C19 inhibitor affects ticlopidine activity in vivo. This study aimed to test the ability of methadone in changing ticlopidine pharmacokinetics. METHODS We conducted a case-control study in 10...