شیران, محمدرضا
دانشیار، مرکز تحقیقات ایمونوژنتیک، دانشکده پزشکی، دانشگاه علوم پزشکی مازندران، ساری، ایران
[ 1 ] - مروری بر فارماکوکنتیک و فارماکودینامیک وریکونازول
Voriconazole is an antifungal triazole, approved for management of invasive fungal diseases in patients. It is absorbed during two hours and its serum levels will be above 90%, based on the underlying factors, when the drug is administered orally. Voriconazole shows a propotional increase in an area under the plasma concentration-time curve (AUC), with increasing dose. Plasma protein binding of...
[ 2 ] - The efficacy and safety of two different doses of caffeine in respiratory function of preterm infants
Background: Caffeine is widely used for prevention of apnea and helps successful extubation from mechanical ventilation. It facilitates the transition from invasive to noninvasive support and reduces duration of continuous positive airway pressure (CPAP) in preterm infants. The optimum caffeine dose in preterm infants has not been well-studied in terms of benefits and risks. We compared efficac...
[ 3 ] - Influence of methadone on clopidogrel in addicts on methadone maintenance therapy
Background: Clopidogrel is a prodrug that converts in the liver to an active thiol metabolite, which irreversibly inhibits the platelet P2Y12 adenosine diphosphate receptor. It seems that methadone as CYP2C19 inhibitor affects ticlopidine activity in vivo. This study aimed to test the ability of methadone in changing ticlopidine pharmacokinetics. Methods: We conducted a case–control st...
[ 4 ] - Detection of CYP2C18 m1, and m2 Alleles within an Iranian Population (Mazandaran) Using Denaturing High-Performance Liquid Chromatography (DHPLC)
Background: Genetic polymorphisms of cytochrome p450 in humans are the main cause of differences in the metabolism. The allele and genotype frequencies of CYP2C19 and CYP2C9 have been studied in some Iranian populations. The aim of present study was to examine the frequencies of CYP2C18m1, and CYP2C18m2, alleles in the Mazandarani ethnic group among Iranian Population. Materials and Methods: I...
[ 5 ] - Frequencies of two CYP2C19 defective alleles (CYP2C19*2, and *3) among Iranian population in Mazandaran Province
Background: Cytochrome P450 2C19 (CYP2C19) is a polymorphically expressed enzyme that shows marked interindividual and interethnic variation. CYP2C19*2 and CYP2C19*3 are the most frequently identified defective alleles in Orientals and Caucasian poor metabolizers (PM). The aim of this study was to investigate the frequencies of CYP2C19*1, CYP2C19*2 and CYP2C19*3 alleles and CYP2C19 genotypes in...
[ 6 ] - Contamination Rate of Eggs with Mycotoxins in Mazandaran Province, Iran 2019
Background and purpose: Contamination of food with mycotoxins is among the major threats to food security, and human and animal health that cause significant economic losses in countries. This contamination is found in poultry and animal products and can pose risks to human health. Despite the mass production and consumption of egg, this product has not been well evaluated for the presence of m...
[ 7 ] - Preparation and evaluation of chitosan-zein film containing free and encapsulated ethanol extract of kak kosh biabani Pulicaria gnaphalodes (Vent.) Boiss.
Background: Today, the tendency to use biodegradable biopolymers as one of the appropriate technologies to prevent food oxidation has received much attention. Objective: The aim of the present study was to produce a new biodegradable films containing free ethanolic extracts and nanocapsules of kak kosh biabani (Pulicaria gnaphalodes (Vent.) Boiss.), in order to investigate the antioxidant prope...
[ 8 ] - Structural Equation Modeling in Awareness and Attitude of Consumers Toward Food Labels
Background and purpose: Labelling is a communication tool between the manufacturer/ distributor and customer which includes all optional and mandatory information about a product. Awareness and education are the primary steps in forming a positive attitude toward food labels. The purpose of this study was structural equation modeling in awareness and attitude of consumers about food labels in S...
[ 9 ] - Investigating the Role of Education on Rice Waste Management with Emphasis on Environmental Protection and Health
Background and purpose: Waste accumulation has very negative impacts on human health and the environment, but if managed properly, it can help in increasing food safety of the community. Agricultural extension and education as one of the main pillars of modern agriculture can play an effective role in agricultural productivity and waste and in general improve the living conditions of farmers. T...
[ 10 ] - Determination of Pollutants and Mineral Element Levels in Widely Consumed Medicinal Plants in Mazandaran Province
Background and purpose: Extensive use of various forms of medicinal plants makes it necessary to continuously monitor the production and supply of these plants. Also, it is important to study metal and pesticide contaminants in medicinal plants in order to prevent hazards from their consumption. This study aimed at investigating the pollutants and mineral element levels in widely consumed medic...
[ 11 ] - Viability of Probiotic Bacteria in Yogurts Produced in Mazandaran Province Exposed to Simulated Gastrointestinal Conditions
Background and purpose: Production of functional foods is one of the most important achievements in food industry and using these products provides the convergence of two important events in life; namely receiving nutrients from the diet and promoting health for consumers at the same time. This study aimed to verify the viability of microorganisms and stability of these microorganisms in diges...
نویسندگان همکار