Introduction: The current investigations on Health Equity, primarily point to the harmful health consequences of being in a stressful social hierarchy. The repetitive nature of social conflicts seems to favor the induction of hyperalgesia or hypoalgesia both in rodents and humans, and it can also affect the immune system. In this study, the effects of changes in social status on pain percept...

To investigate the effects of the two-pore-domain potassium (K2P) channel TASK-3 in a syngeneic murine model for malignant glioma. Malignant or high-grade glioma (WHO grade III and IV) are the most common and most aggressive primary brain tumors in adults. Despite aggressive multimodal therapy, the outcome of patients with malignant glioma remains poor. However, recent phase I and II trials hav...

the laboratory mouse is recognized as the pre-eminent model for genetic research. awareness of chromosomal patterns of experimental animals increases their value for a variety of different fields of study. we aimed to study mitotic chromosome preparations from nih, c57bl/6 and razi strains of mice, which are outbred, inbred and partially inbred laboratory mice respectively. bone marrow cells we...

this experimental study was conducted to assess of effectiveness of two nanogold concentrations against cutaneous leishmaniasis (cl) caused by iranian strain of leishmania major in balb/c mice model. cutaneous lesions were experimentally induced by inoculation with iranian leishmania major promastigotes (mrho/ir/75/er) in 61 balb/c mice. the infected mice were enrolled to four groups: intervent...

background: the intraperitoneal injection is a common method for establishing the experimental animal model infected with parasites. the aim of this study was to investigate if the intraperitoneal injection was another route of trichinella spiralis infection. methods:  from june to july 2015, twenty balb/c mice were intraperitoneally injected with 300 t. spiralis muscle larvae in department of ...

Ascending infection of the uterus with Gram-negative bacteria is responsible for postpartum endometritis in cattle and buffalo and can adversely affect fertility. Development of a laboratory animal model for bovine endometritis would facilitate the understanding of the pathogenesis as it is difficult to conduct controlled experimentation in the native host. In the present study, 30 virgin Swiss...

objective(s):sub-health has been described as a chronic condition of unexplained deteriorated physiological function, which falls between health and illness. in the present study, we evaluated the effects of lycium barbarum polysaccharide (lbp), a polysaccharide fraction purified from lycium barbarum (l. barbarum) on the sub-health mice. materials and methods:the sub-health model mice were buil...

it is well accepted that in experimental model of leishmania major infection, balb/c mice mount a th2 response and produce igg1 predominantly whereas c57bl/6mice enhance th1 response with the biased production of igg2a antibodies. therefore, screening for parasite antigens on the basis of reactivity with sera from infected susceptible or resistant mice might be used for the identification of th...

Prognosis of metastatic breast cancer is very poor which urges the necessity to develop novel potential drug candidates. We assessed two compounds with tri-aryl structures (A and B) for their potency to reduce primary breast tumor growth and lung metastasis in 4T1 mice model. MTT assay, 4T1 mammary mouse model and immunohistochemistry experiments were used in this study. In vitro results exhibi...

introduction: the use of cell phones is widespread and there are public concerns regarding its possible deleterious effects on human health especially on the pregnancy outcomes. in this study, structural changes of the placenta after applying the cell phone radiation were examined in the mice model.   materials and methods: for this work, 40 pregnant balb/c mice were randomly allocated to one c...