erythropoietin (epo) was first known as a factor for red blood cell proliferation and differentiation. recent studies show the effects of epo on immune system. in this study the antihuman leukocyte antibody (anti-hla) titer were determined in five groups of rats, which had been sensitized with human lymphocyte. also, the effects of stimulation's frequency and dose of recombinant human eryt...

background: hepatitis b is an important infectious disease.  since several years ago, mass vaccination against this viral infection has become as part of routine vaccination schedule of iran.  however, some healthy neonates, children and adults fail to generate a protective antibody response after vaccination. objectives: to investigate distribution of hla class-i and class-ii antigens in healt...

background: pulmonary tuberculosis (pt) is one of the endemic diseases in iraq, and among the suggested predisposing factors are alleles of the human leukocyte antigen (hla) system. we sought to investigate the association between hla-class i (a and b) and -class ii (dr and dq) alleles in a sample of pt iraqi patients. methods: lymphocytes of 105 pt patients and 40 controls were phenotyped for ...

the immune response to hepatitis b surface antigen (hbsag) is influenced by several factors, of which hla antigens and balanced secretion of th1/th2 cytokines play important roles. the aim of this study was to evaluate the influence of hla antigens on cytokine secretion by hbsag-stimulated peripheral blood mononuclear cells (pbmc) from healthy neonates vaccinated with recombinant hbsag. pbmcs w...

Indian population is well known for its genetic diversity. Among the numerous endogamous communities, which is restricted very much by custom, marriage and occupation, we have collected a total of 229 individuals from 1996 – 1999 comprising of Parsee, Patels and Vatalia Prajapathi (VP) caste groups. We present here the HLA antigen distribution of these endogamous caste groups and compare their ...

OBJECTIVE The aim of this study was to examine whether the five clinical forms of psoriatic arthritis (PsA) identified by Moll and Wright (Semin Arthritis Rheum 1973;3:55-78) could be clearly distinguished, especially as the disease evolved over time, to analyse whether radiographic features or HLA associations could define subsets with greater precision and to identify predictors of disease ou...

Correspondence HLA B5 and Behget's disease SIR, May we draw your attention again to the inheritance of the HLA B5 antigen and its association with Behcet's disease? The association of the HLA B5 and especially its Bw5l split' 2 with Behcet's disease was established in Japan'`3 and Turkey.4'5 There is also a weak association of B5 and Beh,et's disease in British male patients.5'6 There has been ...

Acute leukemias are characterized by the elonogenic proliferation of haemopoietic progenitor cells arrested in maturation. Clinical manifestations are related to the infiltration of the bone marrow and other tissues by the leukemic blasts. Peripheral blood mononuclear cell (PBMC) from luekemic patients (29)ANLL,(36)ALL and from normal donors(55)were typed for HLADP specificities using microlymp...

Dear Editor: Anti-sperm antibodies (ASAs) are composed of numerous antibodies interacting with multiple sperm antigens that play a role in fertility. In males, ASAs cause ‘immune infertility’ by decreasing sperm counts and normal forms, as well as reducing sperm motility and viability, markedly reducing the likelihood of natural conception [1] . The development of ASA in the male depends on the...