Abstract Monocyte exhaustion reflected in pathogenic inflammation and immune suppression underlies the pathogenesis of sepsis. The objective this study is to define novel approaches alleviating monocyte exhaustion, based on intriguing clinical reports that BCG components may be beneficial reducing polymicrobial infection-triggered sepsis severity. We recapitulated vitrothe development exhausted...

Chemokines participate in various processes of monocyte recruitment including monocyte arrest and migration. Our group and others have demonstrated that growth-related oncogene (GRO)-alpha (CXCL1) can support monocyte arrest in models of inflammation. Here we employed a parallel plate-flow chamber and Transwell reconstitution assay to test whether GRO family chemokines were sufficient for Mono ...

These studies were initiated to investigate monocyte regulation of polyclonal antibody responses of human peripheral blood lymphocytes stimulated by sonicates of periodontally associated bacteria. With pokeweed mitogen (PWM) as a positive reference, the role of monocytes in the peripheral blood lymphocyte response to Streptococcus sanguis and Wolinella HVS was examined by manipulating the numbe...

OBJECTIVE Monocyte activation plays a key role in amplifying both inflammatory and coagulopathic sequelae in patients undergoing on-pump coronary artery bypass graft (CABG) surgery. Off-pump CABG diminishes, but does not eliminate, the systemic inflammatory response and its influence on monocyte activation remains unclear. This study was performed to determine if off-pump CABG suppresses all fe...

OBJECTIVE A growing body of evidence indicates that platelets contribute to the onset and progression of atherosclerosis by modulating immune responses. We aimed to elucidate the effects of oxidized low-density lipoprotein (OxLDL) on platelet-monocyte interactions and the consequences of these interactions on platelet phagocytosis, chemokine release, monocyte extravasation, and foam cell format...

Erythrophagocytosis refers to the removal of old and damaged red blood cells by leukocytes and macrophages. Observation of erythrophagocytosis in peripheral blood smear is a rare phenomenon that is mostly observed in paroxysmal cold hemoglobinuria and sporadically in some other pathological conditions. Here, we report a case of erythrophagocytosis by monocyte in peripheral blood of a patient wi...

Graphene and titanium carbide MXene variants significantly reduced bacterial endotoxin induced THP-1 monocyte IL-8, IL-6 TNF-α cytokine production.

Psoriasis is associated with comorbidities, such as cardiovascular disease (CVD), both being chronic diseases a systemic inflammatory component, and genetically linked the NLRP3 inflammasome. Although inflammasome has important implications in pathogenesis of atherosclerosis, its role psoriasis remains unexplored. In this study, we investigate correlation between different markers CVD inflammat...