Morphea is an inflammatory skin disease resulting in sclerosis of underlying tissues which causes functional limitations and cosmetic sequalae that negatively impact quality life. Previous health-related life (HRQoL) patient reported outcome (PRO) studies have focused on children a validated measure, the Localized Scleroderma Quality Life Instrument (LoSQI), has been developed. No PRO measure e...

A 67-year-old woman was evaluated for a worsening asymptomatic rash located on her torso, back, and legs. She denied any chills or fevers, reported feeling otherwise well. Clinically, large brownish, slightly atrophic plaques were seen the torso suggestive of either morphea granulomatous condition. Histopathologic examination revealed an increase in interstitial histiocytes infiltrating between...

CONTEXT Localized scleroderma (morphea) is characterized by fibrosis of skin and subcutaneous tissue. Granuloma annulare is a relatively common disease that is characterized by dermal papules and arciform plaques. CASE REPORT Here, we present the case of a 42-year-old woman who developed granuloma annulare on the dorsum of her feet and abdominal region, and morphea on the anterior side of her...

Introduction: Skin can be the site of manifestations of many systemic diseases. Morphea which is also includes thickening & hardening of skin & sub cutaneous tissues may have a varying range of manifestations. Surgery is rarely indicated. Case Report: A 30 year old female came with complaints of dark brown sclerotic plaque over the upper half of the right thigh with restriction of movements at ...

This review summarizes the literature on scleratrophic skin lesions as a manifestation of a Borrelia infection. An association of morphea with Lyme borreliosis was mainly reported from Middle-European Countries, Japan and South America. B. afzelii has been identified predominantly from the chronic skin lesions of acrodermatitis chronica atrophicans (ACA) and has been cultivated from morphea les...

Morphea is a skin disease characterized by local skin inflammation and fibrosis. Extracutaneous manifestations have been described with this disease including inflammatory arthritis. We describe a case of morphea who developed inflammatory polyarthritis and sacroiliitis coincident with new skin lesions.

Morphea is a rare fibrosing disorder of the skin and underlying tissues. Circumscribed morphea presents with less than three discrete indurated plaques and breasts are commonly affected in women. We report the case of a 12-year-old female with a right infra-areolar, nontender, brownish patch and asymmetry of the right breast with 2 years of evolution. Skin biopsy showing thickening of the derma...

Morphea is one of diseases characterised by fibrosis of the skin and subcutaneous tissue. It is a chronic disease that does not shorten the life of the patient, yet significantly affects its quality. The group of factors responsible for its pathogenesis is thought to include disturbed functioning of endothelial cells as well as immune disturbances leading to chronic inflammatory conditions, acc...

BACKGROUND Axillary artery is known to show different variations mostly in its branching pattern. Similarly, the origin of profunda brachii is often encountered with abnormality. Therefore, when the vascular variations in the upper limb persist, mostly it is confined to its branching pattern followed by its variant origin. But, among all the reported variations of profunda brachii, its variant ...

Climate control of nutricline depth in the equatorial Atlantic can be monitored by variations in the abundance of the phytoplankton species Florisphaera profunda. A conceptual model, based on in situ evidence, associates high abundances of F. profunda with a deep nutricline and low abundances with a shallow nutricline. A 200,000-year record of F. profunda relative abundances, obtained from a de...