Morphea profunda is a rare disease that mainly affects young women and often has a progressive course with physical and psychological sequelae. The skin becomes sclerotic after an initial inflammatory reaction and joint contractures can develop. The aetiology is unknown. Until now, no successful therapy has been proven for this morphea variant. On the basis of new insights into the key role of ...

1. Torrelo A, Suárez J, Colmenero I, Azorín D, Perera A, Zambrano A. Deep morphea after vaccination in two young children. Pediatr Dermatol. 2006;23:484--7. 2. Benmously Mlika R, Kenani N, Badri T, Hammami H, Hichri J, Haouet S, et al. Morphea profunda in a young infant after hepatitis B vaccination. J Am Acad Dermatol. 2010;63:1111--2. 3. Bukhari I, Al Breiki S. Post vaccination localized morp...

1. Torrelo A, Suárez J, Colmenero I, Azorín D, Perera A, Zambrano A. Deep morphea after vaccination in two young children. Pediatr Dermatol. 2006;23:484--7. 2. Benmously Mlika R, Kenani N, Badri T, Hammami H, Hichri J, Haouet S, et al. Morphea profunda in a young infant after hepatitis B vaccination. J Am Acad Dermatol. 2010;63:1111--2. 3. Bukhari I, Al Breiki S. Post vaccination localized morp...

We report a new case of postvaccination morphea profunda (MP) in a child and discuss its different clinical presentations, prognosis, and therapy and its relationship with "solitary morphea profunda." A 2-year-old healthy girl presented with an induration of the anterior aspect of the left thigh of 9 months duration. The lesion had appeared 3 months after a third dose of diphtheria-tetanus-pert...

Morphea is an inflammatory skin condition leading to fibrosis of the and subcutaneous tissue which produces cosmetic functional impairment (FI). Few studies have systematically examined demographic clinical features morphea associated with FI, making it difficult stratify patients for screening FI based on risk. To address this gap, we performed a multicenter cross-sectional analysis adults chi...

T he prevalence of morphea in childhood is not well established, but reports suggest that approximately two-thirds of linear morphea cases occur before age 18 years, and 20% to 30% of morphea cases overall begin in childhood. Studies have described substantial morbidity in children with morphea, but to our knowledge none has addressed the disease effects when the patients reach adulthood (age 1...

An 89-year-old man presented with a 3-year history of progressive oropharyngeal dysphagia with both solids and liquids. He had no fatigability of chewing or swallowing but had difficulty propelling the bolus back to his posterior pharynx. His dysphagia was profound, and he had lost over 20 pounds of weight. He twice developed aspiration pneumonia. He was otherwise in good health and had longsta...