For multiple sclerosis, genome wide association studies and follow up studies have identified susceptibility single nucleotide polymorphisms located in or near CLEC16A at chromosome 16p13.13, encompassing among others CIITA, DEXI and SOCS1 in addition to CLEC16A. These genetic variants are located in intronic or intergenic regions and display strong linkage disequilibrium with each other, compl...

how to cite this article: inaloo s, haghbin s. multiple sclerosis in children. iran j child neurol. 2013 spring;7(2):1-10.   multiple sclerosis (ms) is the most important immune-mediated demyelinated disease of human which is typically the disease of young adults. a total of 4% to 5% of ms population are pediatric. pediatric ms is defined as the appearance of ms before the age of sixteen. about...

background: there have  been  several studies  done  on the role of metals in the occurrence  of multiple sclerosis (ms) disease, but their roles have not been confirmed yet. because of the lack of information on this issue, this study compared  the  serum  level  of  copper and zinc in ms patients with their levels in a control group. methods: this  was  an  analytical,  cross-sectional  study...

multiple  sclerosis  (ms) is  an  autoimmune  multifactorial  degenerative  disease  with detrimental affliction on central nervous system. mhc class i chain- related genea,b(mica and micb) are nonclassical human leukocyte antigens that can affect on some diseases and also on transplantation. the purpose of this study was to evaluate the mica and micb mrna expression in multiple sclerosis patie...

multiple sclerosis (ms) is an inflammatory disorder, in which neurons in central nervous system (cns) become demyelinated .ms is named for its formation of plaques due to sclerosis of myelin. variable degree of demyelination results in mild, mediate or severe symptomatic episodes of this disease. it is commonly characterized by recurrent relapses and often followed by severe neurological disabi...

patients and methods in this study, a total of 92 patients with relapsing-remitting multiple sclerosis (rrms) were randomly allocated into three equal groups; each treatment group received one of the foregoing drugs (cinnovexr, rebif and betaferon) for one year. at the beginning and end of the study, patients ‘ edss was measured and compared. results in this study, the relative frequency of fem...

multiple sclerosis (ms) is a demyelinating neuro- inflammatory autoimmune disease of the central nervous system. genetic predisposition has long been suspected in the etiology of this disease. the association between mthfr polymorphisms and ms has been ivestigated in different ethnic groups. we investigated the association between mthfr c677t and a1298c missense variants and ms in 180 patients ...