نتایج جستجو برای: n2a cell line

تعداد نتایج: 1969455  

Journal: :iranian biomedical journal 0
علی زارعی محمودآبادی ali zaree mahmodabady حمید رضا جوادی hamid reza javadi مهدی کمالی mehdi kamali علی نجفی ali najafi زهرا حجتی zahra hojati

background: rna interference (rnai) is the mechanism of gene silencing-mediated messenger rna degradation by small interference rna (sirna), which becomes a powerful tool for in vivo research, especially in the areas of cancer. in this research, the potential use of an expression vector as a specific sirna producing tool for silencing of bcr-abl in k562 cell line has been investigated. methods:...

Journal: :avicenna journal of medical biotechnology 0

expression of receptor tyrosine kinase ror1 in a wide variety of cancers has emerged as a new era focusing on targeting this receptor in cancer therapy. our preliminary re-sults indicate the presence of a truncated transcript of ror1 in tumor cells. the trun-cated ror1 encompasses extracellular and transmembrane domains, lacking catalytic kinase domain (ror1-ecd). as enzyme activity is highly d...

Journal: :Endocrinology 2009
Robert J Denver Keith E Williamson

Brain development is critically dependent on thyroid hormone (T(3)). Krüppel-like factor 9 (Klf9) is a T(3)-inducible gene in developing rat brain, and several lines of evidence support that KLF9 plays a key role in neuronal morphogenesis. Here we extend our findings to the mouse and demonstrate the presence of a functional T(3) response element (T(3)RE) in the 5' flanking region of the mouse K...

Journal: :Revista de saude publica 2004
Yeda L Nogueira

OBJECTIVES No population-based studies have been conducted to show the potential for the use of virological diagnosis of the rabies virus. The objective of the present study was to estimate accuracy parameters for the isolation of the rabies virus in McCoy cells as an alternative method and to compare this with the use of murine neuroblastoma (N2A) cells, which is considered to be a reference m...

Journal: :The Journal of Cell Biology 1992
B A Murray J J Jensen

The adhesion of embryonic chicken retinal cells and mouse N2A neuroblastoma cells to purified embryonic chicken retinal NCAM adsorbed on a solid substratum was examined using a quantitative centrifugal adhesion assay. Both cell types adhered to NCAM and the adhesion was specifically inhibited by monovalent anti-NCAM antibody fragments. N2A cell adhesion depended on the amount of NCAM applied to...

Journal: :Antimicrobial agents and chemotherapy 2007
Alessandra Pani Claudia Norfo Claudia Abete Claudia Mulas Marirosa Putzolu Sergio Laconi Christina Doriana Orrù M Dolores Cannas Sarah Vascellari Paolo La Colla Sandra Dessì

Our studies on the role of cholesterol homeostasis in the pathogenesis of scrapie revealed abnormal accumulation of cholesterol esters in ex vivo peripheral blood mononuclear cells (PBMCs) and skin fibroblasts from healthy and scrapie-affected sheep carrying a scrapie-susceptible genotype compared to sheep with a resistant genotype. Similar alterations were observed in mouse neuroblastoma N2a c...

2016

6000 (communication orale) Induction docetaxel platinum 5-FU (TPF) followed by cetuximab-radiotherapy (cetux-RT) versus concurrent chemo-radiotherapy (CT/RT) in patients with N2b/c-N3 non operated stage III-IV squamous cell cancer of the head and neck (SCCHN) : Results of the GORTEC 2007-02 phase III randomized trial. View abstract Abstract 6003 (communication orale) Cetuximab-radiotherapy vers...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2010
Valentin Lulevich Christopher C Zimmer Hyun-seok Hong Lee-way Jin Gang-yu Liu

By using a highly sensitive technique of atomic force microscopy-based single-cell compression, the rigidity of cultured N2a and HT22 neuronal cells was measured as a function of amyloid-beta42 (Abeta42) protein treatment. Abeta42 oligomers led to significant cellular stiffening; for example, 90-360% higher force was required to reach 80% deformation for N2a cells. Disaggregated or fibrillar fo...

Journal: :International journal of clinical and experimental pathology 2014
Wei-Dong Xiao Ai-Xi Yu Dan-Li Liu

OBJECTIVE This study aims to investigate the neuroprotective effect of Rho kinase inhibitor fasudil hydrochloride in ischemia/reperfusion injury N2a neuron. METHODS In vitro, N2a cells induced by ischemia and ischemia-reperfusion were treated with fasudil hydrochloride, cell damage was analyzed by MTT. On the other hand, the cytoskeleton of N2a cells was scanned through immunofluorescence tec...

Objective(s): Neurodegenerative diseases have been associated with glutamatergic dysfunction. Berberine, an isoquinoline alkaloid broadly present in different medicinal herbs, has been reported to have neuroprotective effect. In the present study, the effects of berberine against glutamate-induced oxidative damage and apoptosis were investigated. Materials and Methods: The cultured PC12 and N2a...

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