Neisseria meningitidis is a facultative pathogen bacterium which is well founded with a number of adhesion molecules to facilitate its colonization in human nasopharynx track. Neisseria meningitidis is a major cause of mortality from sever meningococcal disease and septicemia. The Neisseria meningitidis adhesion, NadA, is a trimeric autotransporter adhesion molecule which is involved in cell ad...

Worldwide Chlamydia trachomatis and Neisseria gonorrhoeae are two of the most prevalent sexually transmitted pathogens. The present study aimed to estimate the prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae infection in women from Taif, western region, KSA. A polymerase chain reaction (PCR) method was carried using DNA extracted from 144 female urine samples. Primer pairs specifi...

Bacteriocin typing has been described previously and proposed for typing gonococci. A survey has been made of 150 strains of N. gonorrhoeae from various places to determine the feasibility of a gonocin typing system. All strains were found to produce an inhibitory substance which inhibited all strains of gonococci tested, one strain of Neisseria flavescens, two strains of Neisseria meningitidis...

Neisseria meningitidis N. meningitidis, or meningococcus, is an aerobic, gramnegative diplococcus, closely related to N. gonorrhoeae, and to several nonpathogenic Neisseria species, such as N. lactamica. The organism has both an inner (cytoplasmic) and outer membrane, separated by a cell wall. The outer membrane contains several protein structures that enable the bacteria to interact with the h...

Neisseria gonorrhoeae is one of the leading antimicrobial resistance threats worldwide. This study determined the MICs of closthioamide to be 0.008 to 0.5 mg/liter for clinical N. gonorrhoeae strains and related species. Cross-resistance with existing antimicrobial resistance was not detected, indicating that closthioamide could be used to treat drug-resistant N. gonorrhoeae.

PCR-based assays for the identification of Neisseria meningitidis serogroups 29E, X, and Z by detection of specific regions of the ctrA gene are described. The specificities of these assays were confirmed using serogroups A, B, C, 29E, H, W135, X, Y, and Z and nongroupable meningococcal isolates.

Neisseria meningitidis colonizes the nasopharynx and, unlike commensal Neisseria species, is capable of entering the bloodstream, crossing the blood-brain barrier, and invading the meninges. The other pathogenic Neisseria species, Neisseria gonorrhoeae, generally causes an infection which is localized to the genitourinary tract. In order to investigate the genetic basis of this difference in di...

1. Urwin R. Nucleotide sequencing of antigen genes of Neisseria meningitidis. In: Pollard AJ, Maiden MCJ, editors. Meningococcal disease: methods and protocols. Totowa (NJ): Humana Press, Inc.; 2001. p. 157–72. 2. Van der Ley P, Heckels JE, Virji M, Hoogerheut P, Poolman JT. Topology of outer membrane porins in pathogenic Neisseria spp. Infect Immun. 1991;59: 2963–71. 3. Frasch CE, Zollinger WD...

A glucose-negative group B strain of Neisseria meningitidis isolated from a meningitis case is described. A brief review of Neisseria identification procedures is also presented.