Effects of L-arginine (L-arg) and aminoguanidine (AG) on the nephrotoxicity induced by cyclosporine (CsA) were investigated. After injection of CsA (15 mg kg(-1) day (-1)i.p. for 10 days), it induced nephrotoxicity, manifested biochemically by a significant elevation of serum urea and creatinine. In addition, a marked increase in lipid peroxides measured as malondialdehyde (MDA) as well as a si...

conclusions the result of this study indicated that nephrotoxicity rate among patients treated with vancomycin is under the influence of the poisoning by nephrotoxicants. higher vancomycin trough level was associated with increasing nephrotoxicity rate. results one hundred and fifty-four vap patients’ profiles were reviewed, of whom 110 were eligible. the median age was 33.50 (12 to 94) years a...

background and methodology: gentamicin is a broad-spectrum antibiotic with restricted application in man and stock due to its side effects such as nephrotoxicity and autotoxicity. cinnamon bark has antioxidant properties. this is the first study on the protective effects of the hydroalcoholic extract of cinnamon on gentamicin-induced nephrotoxicity.methods and materials: thirty-six mature femal...

background and objective: gentimicin is an antibiotic from the family of aminoglycosides used in the treatment of infections resulted from gram-negative bacteria, the use of which is limited due to its nephrotoxicity. in this study the histological effect of cinnamon on the nephrotoxicity resulted from gentimicin in rats is investigated because of the antioxidant properties of cinnamon.material...

background and purpose: gentamicin-induced nephrotoxicity results from the production of reactive oxygen species (ros) in the kidneys, and since cinnamon has antioxidant properties, this research studied the effects of cinnamon extract on the prevention and treatment of gentamicin-induced toxicity in immature white rats.materials and methodology: in this study 36 immature female wistar rats wer...

introduction: cisplatin (cp) therapy may disturb cardiovascular system control. the objective of this study was to find baroreflex sensitivity (brs) in cp-induced nephrotoxicity in rats. materials and methods: eighteen male and female wistar rats were randomly assigned to two groups treated with cp (2.5 mg/kg/day) and the vehicle, for five consecutive days, and then were subjected to surgical p...

BACKGROUND In 1995 - 1996, we switched from a once-daily Sandimmune dose to a twice-daily dose regimen of Neoral. Concurrent with the switch we changed our target trough level from 100 microg/l at 24 hours to the generally accepted 12-hour level of 150 microg/l. We performed a retrospective cohort study to assess cyclosporine toxicity following this switch and to identify risk factors for nephr...

background: gentamicin (gm) is used as antibiotic for gram-negative infections, but its administration is limited due to a side-effect of nephrotoxicity. it was attempted to investigate the effect of althaea officinalis flower extract (aofe) against nephrotoxicity induced by gm in male rats. methods: 30-year-old male wistar rats were divided into five groups. group 1 as a negative control group...

background: prolonged use of cyclosporine a for prevention of allograft rejection is associated with nephrotoxicity development. naringenin and olive oil are beneficial dietary antioxidants with potential renoprotective properties. this study aimed to evaluate the therapeutic effect of naringenin and olive oil in alleviating cyclosporine induced nephrotoxicity in rats by the assessment of renal...

Tacrolimus, a calcineurin inhibitor, is clinically used as an immunosuppressive agent in organ transplantation, but its use is limited due to its marked nephrotoxicity. The present study investigated the effect of olmesartan (angiotensin receptor blocker) on tacrolimus-induced nephrotoxicity in rats. A total of 24 rats were divided into four groups, which included control, tacrolimus, tacrolimu...