Yeasts utilize tryptophan for the synthesis of nicotinic acid under aerobic, but not under anaerobic, conditions. Under aerobic conditions of growth, radioactivity from tryptophanJ4C uniformly labeled in the benzene ring and 14C!-carboxyl-labeled 3-hydroxyanthranilic acid is incorporated into nicotinic acid. Under anaerobic conditions, little radioactivity from these compounds is incorporated i...

Zinc coatings are commonly used to protect steel from different types of corrosion. However, zinc is an electrochemical reactive metal; applying surface treatment galvanized materials usually necessary increase the system's lifetime. An alternative method for improving service life these use corrosion inhibitors. Nicotinic acid, chemically formulated as C 5 H 4 NCO, a water-soluble vitamin. It ...

Niacin: Nicotinic Acid, Nicotinamide, and Inositol Hexanicotinate Introduction Niacin is the vitamin B3 and has fundamental roles as part of reduction/oxidation coenzymes involved in energy metabolism, amino acid metabolism, and detoxification reactions for drugs and other substances. Niacin comes from in several forms: (1) nicotinic acid (pyridine-3carboxylic acid) (Burgeois et al. 2006), (...

In this study, we present the identification and characterization of hamster and guinea pig nicotinic acid receptors. The hamster receptor shares approximately 80-90% identity with the nucleotide and amino acid sequences of human, mouse, and rat receptors. The guinea pig receptor shares 76-80% identity with the nucleotide and amino acid sequences of these other species. [(3)H]nicotinic acid bin...

The use of nicotinic acid derivatives in the field of medicinal, biomedical industries, production of cosmetics, pesticides, agro chemical industries and its biological activities have been studied extensively over the past decades. In this chapter, one of such nicotinic acid derivative called Nicotinic Acid Ethyl Ester (also known ethyl nicotinate, Ethyl 3-pyridinecarboxylate and 3-pyridinecar...

It has now been definitely established that there exists an interchangeability of nicotinic acid and tryptophan in the nutrition of some animals on diets deficient in the vitamin and containing only suboptimal amounts of the amino acid (1-S). Because the dog has been employed as the experimental animal in the classical investigations on nicotinic acid deficiency, it seemed of interest to determ...

Knowledge of the accessory growth factors concerned in the physiology of lactose-fermenting yeasts was needed in an investigation of fermentation that was being conducted by the Bureau of Dairy Industry. Since information on nicotinic acid requirements for the growth of yeasts not fermenting lactose was at best fragmentary and incomplete and information on lactose-fermenting yeasts was complete...

Objective(s):Involvement of tyrosinase in the synthesis of melanin and cell signaling pathway has made it an attractive target in the search for therapeutic inhibitors for treatment of different skin hyperpigmentation disorders and melanoma cancers. Materials and Methods: In the present study, we conducted a comprehensive kinetic analysis to understand the mechanisms of inhibition imposed by 2-...

Trigonelline, N-methyl nicotinic acid, was first noted in the seeds of Trigonella joenum-graecum (the fenugreek) (1) and has since been found in the seeds and tubers of many species (2,3) as well as in leaves of one species of pea (4). Although one may assume that trigonelline arises metabolically from nicotinic acid, definitive evidence has been lacking. In the course of several attempts to de...

The G-protein-coupled receptor GPR109A (HM74A/PUMA-G) has recently been shown to function as a receptor for nicotinic acid (niacin) and to mediate its antilipolytic effects. Nicotinic acid is able to strongly raise plasma levels of high-density lipoprotein cholesterol, a property that distinguishes nicotinic acid from other lipid-lowering drugs. To investigate the structural determinants of GPR...