Coronary spasm can usually be controlled by administration of Ca antagonists. However, there are some cases of coronary spasm whose attacks cannot be controlled even with large doses of Ca antagonist and/or its combination with nitrates. Here we describe the case of a 41-year-old man whose attacks of coronary spasm were resistant to the combined administration of nitrates, Ca antagonists, and a...

lingual long-acting nitrates more prolonged than that achieved by nitroglycerin. It is likely that the duration of action of the sublingual nitrates is not as long as would be ideal, merely more prolonged than that achieved by nitroglycerin: a 1-21/2 hour duration of action seems most likely. Evidence that oral "long-acting nitrates" have a prolonged duration of action is, we agree, lacking. Al...

Photolysis is shown to be a major sink for isoprene-derived carbonyl nitrates, which constitute an important component of the total organic nitrate pool over vegetated areas. Empirical evidence from published laboratory studies on the absorption cross sections and photolysis rates of α-nitrooxy ketones suggests that the presence of the nitrate group (i) greatly enhances the absorption cross sec...

Mitochondrial aldehyde dehydrogenase (ALDH-2) was recently identified to be essential for the bioactivation of glyceryl trinitrate (GTN). Here we assessed whether other organic nitrates are bioactivated by a similar mechanism. The ALDH-2 inhibitor benomyl reduced the vasodilator potency, but not the efficacy, of GTN, pentaerythritol tetranitrate (PETN), and pentaerythritol trinitrate in phenyle...

Fluxes of nitrates between snow surfaces and the atmosphere in the European high arctic H. J. Beine, F. Dominé, A. Ianniello, M. Nardino, I. Allegrini, K. Teinilä, and R. Hillamo C.N.R. – IIA, Roma, Italy CNRS – LGGE, Grenoble, France C.N.R. – ISAC, Bologna, Italy FMI – Air Quality Research, Helsinki, Finland Received: 24 October 2002 – Accepted: 4 December 2002 – Published: 6 January 2003 Corr...

nitration of phenol and various 4-substituted phenols with cu(no3)2.3h2o, cu(no3)2.3h2o/sio2, 9h2o and cr(no3)2. 9h2o in different anhydrous organic solvents are investigated. high selectivity ratio of para vs ortho isomers has been observed. mono- and dinitro compounds from phenol and 4-substituted phenols by choosing the proper solvents and reaction conditions, are also obtained with high sel...