Beyond molecular chemistry based on the covalent bond, supramolecular chemistry aims at developing highly complex chemical systems from components interacting through noncovalent intermolecular forces. Over the past quarter century, supramolecular chemistry has grown into a major field and has fueled numerous developments at the interfaces with biology and physics. Some of the conceptual advanc...

An efficient synthesis of original bis-β-cyclodextrin-[2]cryptorotaxanes in moderate to high yields is described. A synthetic approach based on the template-directed self-assembly threading process in aqueous medium gives a structure stabilized exclusively through non-covalent interactions. This procedure reveals a simple and efficient way to prepare highly organized supramolecular receptors fr...

The interaction of small molecules with larger non-covalent assemblies is important across a wide range of disciplines. Here, we apply two complementary NMR spectroscopic methods to investigate the interaction of various fluorophenol isomers with sunset yellow. This latter molecule is known to form non-covalent aggregates in isotropic solution, and form liquid crystals at high concentrations. W...

Biological materials. recently. are the building blocks of several self-assembling peptide and protein systems.The main challenge In molecular self-assembly is to design molecular building blocks that can undergospontaneous organization. These cyche peptides were produced by an alternating fl'ell number of D- and Laminoacids.which interact through non-covalent interactions co an array of selfas...

We have investigated the reversible hetero-Diels-Alder reaction of 1,2-oxazines derived from a peralkylcyclopentadiene and a series of nitrosocarbonyl dienophiles. The nature of the dienophile was found to impart broad tunability to the dynamic character of the oxazine adducts. The reversibility was also observed in polymeric systems. The fidelity of the reaction and tunable sensitivity toward ...

Analysis of pH and cosolvent effects on protein structure is a popular study in food biophysics research since the function primarily dependent its structure. The structure-function relationship could be well reflected changes non-covalent interactions protein. In this aspect, present work deals with Fourier transform infrared (FT-IR) spectroscopy analysis ovalbumin (OVA) different conditions w...

Thiosemicarbazones (TSCs) possess significant antimalarial properties believed to be linked to the inhibition of major cysteine proteases, such as falcipain-2, in Plasmodium falciparum. However, the binding modes of TSCs to the active site of these enzymes are not clear. As a result of this, the nature of the bonding interactions between the active site of falcipain-2 and different derivatives ...