BACKGROUND CYP2C9 and VKORC1 genotyping has been advocated as a means of improving the accuracy of warfarin dosing. However, the effectiveness of genotyping in improving anticoagulation control and reducing major bleeding has not yet been compellingly demonstrated. Genotyping currently costs $400 to $550. METHODS AND RESULTS We constructed a Markov model to evaluate whether and under what cir...

The search for a safer and more tolerable anticoagulant alternative to warfarin has been the holy grail of thromboembolic research for decades. With its capacity to reduce the risk of ischemic stroke by nearly two thirds in patients with atrial fibrillation, warfarin remains one of the most powerful preventive tools in all of medicine.1 But in the 57 years since the drug was introduced, generat...

Abstract This paper suggests a fuzzy MCDM (multiple criteria decision-making) approach, where ratings of alternatives versus criteria and weights of criteria are assessed in fuzzy numbers or linguistic values represented by fuzzy numbers. Criteria are classified into cost and benefit ones. In the proposed method, the ratings assigned by decision makers to each alternative versus each criterion ...

Long term oral anti-coagulation with vitamin K antagonists is a risk factor of hemorrhagic or thromebomlic complications. Periodic laboratory testing of international normalized ratio (INR) and a subsequent dose adjustment are therefore mandatory. The use of home testing devices to measure INR has been suggested as a potential way to improve the comfort and compliance of the patients and their ...

We propose a complementary and fast approach to study galaxy rotation curves directly from the sample data, instead of individual fits. With this approach, some relevant tests can be done analytically. It is based on dimensionless difference between observational curve expected one baryonic matter ($\delta V^2$) as function normalized radius $r_n$ (i.e., for all galaxies, $0 < r_n 1$). Using 15...

objective: type 2 diabetes is amongst the most common chronic illnesses in iran. its prevalence is increasing and it has significant economic importance. the aim of this study was to estimate direct therapeutic and non-therapeutic costs of type 2 diabetes patients referred to the diabetes research center of yazd in 2012. materials and methods: this cross-sectional study was carried out on 250 t...

Normalized Equation and Decomposition Analysis: Computation and Inference This paper joins discussions on normalized regression and decomposition equations in devising a simple and general algorithm for obtaining the normalized regression and applying it to the Oaxaca decomposition. This resolves the invariance problem in the detailed Oaxaca decomposition. An algorithm to calculate an asymptoti...