Several lines of evidence suggest that some neurotoxicity in AD is due to proteolytic fragments of APP. In this study, we compared the potency of neurotoxicity induced by CT with that of A-beta neurotoxicity and our results showed that various CT peptide fragments (CTFs; CTF99, AICD, CTF31) caused neurotoxicity in cultured cells and primary cortical neurons, induced strong non-selective inward ...

in this study we produced and purified a high titer of specific and high affin¬ity fab fragments of anti-digoxin antibody. immunization of rabbits with a conju¬gate of the cardiac glycoside digoxin, coupled by a periodate oxidation method to the amino group of lysine in bovine serum albumin resulted in the production of this type of high titer digoxin-specific antibodies with exceptionally high...

Previous experimental studies have indicated that that an autoimmune reaction towards herniated nucleus pulposus may constitute a pathogenetic component in the pathophysiology of sciatica. If an autoimmune reaction would be present, one would expect that exposure of nucleus pulposus to the host would induce an up regulation of antigen-presenting cells, such as monocytes. Autologous nucleus pulp...

Several lines of evidence suggest that some neurotoxicity in AD is due to proteolytic fragments of APP. In this study, we compared the potency of neurotoxicity induced by CT with that of A-beta neurotoxicity and our results showed that various CT peptide fragments (CTFs; CTF99, AICD, CTF31) caused neurotoxicity in cultured cells and primary cortical neurons, induced strong non-selective inward ...

Realistic nuclear reaction cross-section models are an essential ingredient of reliable heavy-ion transport codes. Such codes used for risk evaluation manned space exploration missions as well ion-beam therapy dose calculations and treatment planning. Therefore, in this study, a collection total data has been generated within GSI-ESA-NASA collaboration. The database includes the experimentally ...

introduction: gonadotropin inhibitory hormone (gnih) is believed to be an inhibitor of gonadotropin releasing hormone (gnrh) secretion. the role of gnih in lactational inhibition of gonadotropin secretion is not well known therefore, the aim of the present study was to evaluate the effect of lactation on expression of gnih in these nuclei of lactating and non-lactating rats. methods: ten postpa...

We propose a new approach to probe the spatial extension of valence neutron orbital in 9Be nucleus via 9Be(p,pn)8Be knockout reaction. This property nuclear molecular has not been established previous experimental studies and divergence exists between theoretical descriptions from different perspectives, i.e., antisymmetrized dynamics container pictures cluster dynamics. These are represented b...

Microscopic calculations show a strong parity dependence of the nuclear level density at low excitation energy of a nucleus. Previously, this dependence has either been neglected or only implemented in the initial and final channels of Hauser-Feshbach calculations. We present an indirect way to account for a full parity dependence in all steps of a reaction, including the one of the compound nu...

Foreign body reaction is a rare complication after cochlear implantation. When such complications do occur, they may be intractable and difficult to be cured with antibiotics or surgical revision that may lead to cochlear reimplantation finally. In this article, we presented a patient with foreign body reaction who recovered well after cochlear reimplantation and has been in good health through...