This paper addresses to the Cell Formation Problem (CFP) in which Automated Guided Vehicles (AGVs) have been employed to transfer the jobs which may need to visit one or more cells. Because of added constraints to problem such as AGVs’ conflict and excessive cessation on one place, it is possible that AGVs select the different paths from one cell to another over the time. This means that the ti...

Design of Cellular Manufacturing System involves four major decisions: Cell formation (CF), Group layout (GL), Group scheduling (Gs) and Resource assignment (RA).  These problems should be regarded, concurrently, in order to obtain an optimal solution in a CM environment. In this paper a two stage heuristic procedure is proposed for CF and RA decisions problem. The solution approach contains a ...

In this paper, a multi-objective model is proposed to address the dynamic cellular manufacturing (DCM) formation problem. This model considers four conflicting objectives: relocation cost, machine utilization, material handling cost and maintenance cost. The model also considers the situation that some machines could be shared by more than one cell at the same period. A genetic algorithm is app...

objective: the aim of this study was to investigate the effect of laser assisted hatching on the development and quality of vitrified-warmed 4-cell stage mouse embryos. materials and methods: the vitrified-warmed 4-cell mouse embryos were divided into two groups: control group (without laser assisted hatching) and experiment group (with laser assisted hatching). all embryos in both groups were ...

  A fuzzy goal programming-based approach is used to solve a proposed multi-objective linear programming model and simultaneously handle two important problems in cellular manufacturing systems, viz. cell formation and layout design. Considerations of intra-cell layout, the intra-cell material handling can be calculated exactly. The advantages of the proposed model are considering machining cos...

This paper presents a new, bi-criteria mixed-integer programming model for scheduling cells and pieces within each cell in manufacturing cellular system. The objective of this is to minimize the makespan inter-cell movements simultaneously, while considering sequence-dependent setup times. In CMS design planning, three main steps must be considered, namely formation (i.e., piece families machin...

objective: vitrification has been shown as one of the most effective methods of cryopreservation for mammalian embryos. however, there is no consensus which stage of embryonic development is the most appropriate for vitrification with subsequent maximal development after thawing. this study was carried out to explore and compare the effect(s) of vitrification on mouse 2-cell, 4-cell, 8-cell, mo...

Objective(s): Mitofilin contributes to the maintenance of mitochondrial structure and functions. This study was undertaken to determine the mechanisms underlying its regulation of apoptosis.  Materials and Methods: Mitofilin was knockdowned by specific short hairpin RNA (shRNA) and the stable HeLa cell clone was selected. The autophagy a...