Abstract Intrauterine growth restriction (IUGR) is one of the most common pathologies pregnancy. The cardiovascular consequences IUGR do not disappear in adulthood and can manifest themselves pathological alterations vasomotor control. hypothesis was tested that weakens anticontractile influence NO augments procontractile Rho-kinase arteries adult offspring. To model rat, dams were 50% food res...

Changes in DNA methylation may play a role in the genetic mechanism underlying glucose intolerance in the offspring of mothers with diabetes. Here, we established a rat model of moderate intrauterine hyperglycemia induced by streptozotocin to detect glucose and lipid metabolism of first-generation (F1) and second-generation (F2) offspring. Moderate intrauterine hyperglycemia induced high body w...

Effects of transplacental and trans-breast milk exposure to a foodderived mammary and colon carcinogen, 2-amino-l-methyl-6-phenylimidazo[4,5-¿>]pyridine (PhIP), were investigated in rats. Female SpragueDawley rats were administered PhIP in the diet (100 ppm) for 4 weeks before mating with nontreated males and also during gestation and lac tation. As controls, additional females were maintained...

Han J, Xu J, Long YS, Epstein PN, Liu YQ. Rat maternal diabetes impairs pancreatic -cell function in the offspring. Am J Physiol Endocrinol Metab 293: E228–E236, 2007. First published March 27, 2007; doi:10.1152/ajpendo.00479.2006.—It has been shown that maternal diabetes increases the risk for obesity, glucose intolerance, and Type 2 diabetes mellitus in the adult life of the offspring. Mechan...

Rats fed gestational diets high in multivitamin or folate produce offspring of altered phenotypes. We hypothesized that female rat offspring born to dams fed a gestational diet high in folic acid (HFol) have compromised bone health and that feeding the offspring the same HFol diet attenuates these effects. Pregnant rats were fed diets with either recommended folic acid (RFol) or 10-fold higher ...

background: polycystic ovary syndrome (pcos) is one of the most common reproductive disorders in women. previous studies have shown that prenatal exposure of female fetuses to androgen can be considered an important factor in the development of pcos. objectives: in the present study we aimed to examine the effects of prenatal exposure of female rat fetuses to previously documented doses of test...

Maternal food intake has a significant effect on the fetal environment, and an inadequate maternal diet may result in intrauterine growth restriction. Intrauterine growth restriction newborn rat pups nursed by normal diet-fed dams exhibited rapid catch-up growth, which plays a critical role in the risk for metabolic and cardiovascular disease in later life. Specifically, one-carbon metabolism i...

objective(s) it is well known that prenatal stresses (ps) induce a variety of neurobiological and behavioral alterations, some of them involving the hippocampal formation. this study aimed to determine whether restraint stress influences the neuronal volume and number of granule cells in the hippocampus of adult rat offspring. materials and methods ten wistar pregnant rats were randomly divided...

The role of maternal allergen exposure in the allergenicity of the offspring remains controversial. Some studies have shown that maternal exposure is a risk factor for allergy in the offspring, whereas other studies have shown that maternal exposure induces immune tolerance and protects offspring from allergy disease. Therefore, we utilized maternal rat allergen exposure model to evaluate the o...