نتایج جستجو برای: olig2
تعداد نتایج: 604 فیلتر نتایج به سال:
A fundamental feature of central nervous system development is that neurons are generated before glia. In the embryonic spinal cord, for example, a group of neuroepithelial stem cells (NSCs) generates motor neurons (MNs), before switching abruptly to oligodendrocyte precursors (OLPs). We asked how transcription factor OLIG2 participates in this MN-OLP fate switch. We found that Serine 147 in th...
سابقه و هدف: اولیگودندروسیت ها مسئول تولید میلین در سیستم عصبی مرکزی هستند. فاکتورهای رونویسی نظیر olig1 و olig2 در تنظیم تکوین سلول های اجدادی اولیگودندروسیت نقش مهمی دارند. مهمترین پروتئین سازنده میلین، پروتئین اصلی میلین (myelin basic protein=mbp) است. فاکتور مهارکننده لوکمیا (leukemia inhibitory factor=lif) نقش مهمی در تـولیــد میلین و پـاتـولــوژی مـالتیپــل اسکلـــروزیـس (multiple scleros...
Background and purpose: Oligodendrocytes are responsible for myelin synthesis in the central nervous system (CNS). Olig1 and Olig2 play an important role in regulating the development of oligodendrocyte precursor cells (OLPs). Myelin basic protein (MBP) is the main component of myelin sheath. Leukemia inhibitory factor (LIF) has an important role in myelination and pathology of multiple scleros...
Despite the presence of neural stem cells and ongoing neurogenesis in some regions of the adult mammalian brain, neurons are not replaced in most brain regions after injury. With the aim to unravel factors contributing to the failure of neurogenesis in the injured cerebral cortex, we examined the expression of cell fate determinants after acute brain injuries, such as stab wound or focal ischem...
During spinal cord development, ventral neural progenitor cells that express the transcription factors Olig1 and Olig2, called pMN progenitors, produce motor neurons and then oligodendrocytes. Whether motor neurons and oligodendrocytes arise from common or distinct progenitors in vivo is not known. Using zebrafish, we found that motor neurons and oligodendrocytes are produced sequentially by di...
Abstract Diffuse midline glioma, K27-altered (DMG) is a treatment resistant, uniformly fatal cancer that arises predominantly in children. Next-generation sequencing has revealed the majority of patients with DMG harbor K27M mutations canonical histone variants H3.1 and H3.3, leading to global epigenetic dysregulation an oligodendrocyte precursor cell (OPC) transcriptional profile. DLX2 homeobo...
Human embryonic stem cells (hESCs) offer a platform to bridge what we have learned from animal studies to human biology. Using oligodendrocyte differentiation as a model system, we show that sonic hedgehog (SHH)-dependent sequential activation of the transcription factors OLIG2, NKX2.2 and SOX10 is required for sequential specification of ventral spinal OLIG2-expressing progenitors, pre-oligode...
Adolescence is the critical time for developing proper oligodendrocyte (OL)-neuron interaction and the peak of onset for many cognitive diseases, among which anxiety disorders display the highest prevalence. However, whether impairment of de novo OL development causes neuronal abnormalities and contributes to the early onset of anxiety phenotype in childhood still remains unexplored. In this st...
the purpose of this research was to investigate the effect of mir-429 ectopic over-expression on u251 glioblastoma cell line. it has been shown that mir-429 could target bmk1 and reduce glioma cells invasion. we cultured u251-mir-429 cells and observed changes in their morphology for 14 days. they seemed to become wider with expanded cytoplasm and go on differentiation. neuronal (nefm, nse and ...
A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2.
During development of the vertebrate CNS, the basic helix-loop-helix (bHLH) transcription factor Olig2 sustains replication competence of progenitor cells that give rise to neurons and oligodendrocytes. A pathological counterpart of this developmental function is seen in human glioma, wherein Olig2 is required for maintenance of stem-like cells that drive tumor growth. The mitogenic/gliomagenic...
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