Long-term tolerance of zidovudine treatment was retrospectively analysed in 97 patients with AIDS or AIDS-related complex. After one year of treatment 68% and after two years 87% of the patients had had at least one dose adjustment during their course of therapy. Myelotoxicity was the most common cause (58% of all cases) of dose reductions and therapy interruptions (dose adjustments). At the ti...

conclusions the research revealed that nonsmokers showed better mental health and dyadic adjustment than smokers, thus suggesting that smoking endangers and can impair the tranquility of families and that smoking also threatens the dyadic adjustment of couples. background the mental health and dyadic adjustment of smokers is a matter of serious concern which brings many demerits on mental healt...

This review focuses on the different mechanisms involved in the adjustment of mitochondrial ATP production to cellular energy demand. The oxidative phosphorylation steady state at constant mitochondrial enzyme content can vary in response to energy demand. However, such an adaptation is tightly linked to a modification in both oxidative phosphorylation yield and phosphate potential and is obvio...

The aim of this article is to review the scientific literature on making sense of war and peacekeeping experiences, and it includes an analysis of empirical studies that examine appraisals of military deployment experiences among veterans. Veterans reported more positive than negative effects in the studies of this review. Furthermore, construing positive meaning from war and peacekeeping exper...

A number of approaches have been proposed to determine the weights for multiple attribute decision making. However, resultant are usually assumed be fixed, making it lack tolerance accommodate variation if patterns subsequent data subject change. This article proposes a method facilitate adjustment weights, which accommodates relevant characteristics. model is first constructed that able expres...

conditional  methods  of adjustment  are often used to quantify  the effect  of the exposure on the outcome.  as  a  result,  the  stratums-specific  risk  ratio  estimates  are  reported  in  the  presence  of interaction   between   exposure  and  confounder(s)   in  the  literature,  even  if  the  target  of  the intervention on the exposure is the total population and the interaction itsel...

We design and evaluate a novel layout fine-tuning technique for node-link diagrams that facilitates exemplar-based adjustment of group substructures in batching mode. The key idea is to transfer user modifications on local substructure other the entire graph are topologically similar exemplar. first precompute canonical representation each with node embedding techniques then use it on-the-fly r...

different areas of modern financial tools and processes activities contain the matters like innovations in financial tools engineering and risk management. derivatives and especially stock exchange option is part of this innovation. among all numerical procedures in calculating the value of derivatives and the risk sensitivity parameters of option, binomial models are widely used. in this stud...

In this paper, Black Scholes’s pricing model was developed to study American option on future contracts of Brent oil. The practical tests of the model show that market priced option contracts as future contracts less than what model did, which mostly represent option contracts with price rather than without price. Moreover, it suggests call option rather than put option. Using t hypothesis test...