Pharmacokinetics of intravenous and oral pulsed high-dose dexamethasone were studied in four patients with pemphigus vulgaris. Doses for dexamethasone were varied from 100 to 300 mg. Serum concentrations were measured by high-performance liquid chromatographic procedure with diode assay detection. Bioavailability was assessed by comparing the areas under the serum concentration-time curves foll...

 The aim of this study was to investigate the pharmacokinetic profiles of baicalin, wogonoside, baicalein and wogonin after oral administration of pure baicalin, Radix scutellariae and Scutellariae-Paeoniae couple extracts were administered and the pharmacokinetics profiles were compared between normal and ulcerative colitis rats. The plasma concentrations of the four flavonoids were determined...

Six bufadienolides were isolated from Tylecodon grandiflorus ( Burm .f.) Toelken . The paretic syndrome, krimpsiekte , could be induced in sheep either by repeated oral administration of small quantities of plant material or the intravenous injection of small quantities of certain bufadienolides . A mild to moderate, acute to subacute, multifocal cardiomyopathy was evident in sheep poisoned by ...

A turbidometric assay is described for the quantitative measurement of ampicillin in serum. Standard curves prepared with known concentrations of ampicillin in serum exhibited acceptable linearity over a concentration range of approximately 0.2 to 1.8 mug/ml. Data are presented to show the excellent precision of the assay and the application of the assay to clinical studies. The advantages of t...

The secretion of 3H in the breast milk of seven volunteers was studied over a period of about 48 hours after the oral administration of 5 mg of 3H-prednisolone. A range of 0.07 to 0.23% of the dose per litre was recovered.

Low level intake of drugs from the ingestion of contaminated feed may lead to residue problems in food animals. Sulfadimidine (SDD) was used as a model to determine the residue risk at various doses in laying hens. The drug was administered as a single intravenous injection (100 mg kg(-1) body weight, BW), as a single oral dose (100, 30, 10, 3, 1 mg kg(-1) BW) and via medicated feed for 7 conse...

Our interest in the relative inactivity of progesterone by oral administration reported by several investigators (14) has led us to utilize progesterone-21-Cl4 to ascertain whether the diminished activity could be related to absorption from the gastrointestinal tract. Since our experiments clearly showed that the metabolites were excreted more rapidly in urine than Grady et al. (5, 6) had obser...