Objective(s): Obstructive sleep apnea (OSA) is confirmed to cause lesions in multiple organs, especially in the lung tissue. Tempol is an antioxidant that has been reported to restrain inflammation and oxidative stress, with its role in OSA-induced lung injury being unclear. This study aimed to investigate the beneficial effect of tempol on chronic intermittent hypoxia (IH)-induced lung injury....

introduction: oxidative stress has been implicated in the pathogenesis of various diseases affecting chondrogenesis or the function of articular cartilage. the purpose of the present study was to find the effect of soybean extract on reduction of detoriation effects of oxidativestress in embryonic chondrogenesis in vitro. methods: in order to separate ectoderm from mesenchyme, the limb buds of ...

The responses to oxidative stress induced by chronic exercise (8-wk treadmill running) or acute exercise (treadmill running to exhaustion) were investigated in the brain, liver, heart, kidney, and muscles of rats. Various biomarkers of oxidative stress were measured, namely, lipid peroxidation [malondialdehyde (MDA)], protein oxidation (protein carbonyl levels and glutamine synthetase activity)...

Diabetes mellitus leads to thiamine deficiency and multiple organ damage including diabetic neuropathy. This study was designed to examine the effect of benfotiamine, a lipophilic derivative of thiamine, on streptozotocin (STZ)-induced cerebral oxidative stress. Adult male FVB mice were made diabetic with a single injection of STZ (200 mg/kg, i.p.). Fourteen days later, control and diabetic (fa...

conclusions increment in the number of parity can lead to decrease antioxidant defense mechanisms in multiparous women and their newborns. so, control of oxidative stress is considered to be beneficial in multiparous women. background parturition has been associated with free radicals, itself linked with poor pregnancy outcome. objectives this study aimed to investigate the relationship between...

diazinon is an organophosphate which exerts tissue damages by generating free radicals thereby inducing oxidative stress. the purpose of this study is to determine the protective effect of salvia officinalis l.extract on testes of rats intoxicated by diazinon. in this experimental study, 45 mature male rats were equally divided into three groups of control (c), diazinon (dzn) and diazinon-extra...

Background and objectives: Increased oxidative stress and altered antioxidant levels play an essential role in the pathogenesis of diabetes mellitus. Menopause is associated with increased food intake, weight gain, metabolic disorders, and increased level of inflammatory and oxidative stress factors. This study evaluated effects of oleuropein extract on brain tissue and serum oxidative status i...