Objectives: This study investigates the effects of hydro-alcoholic extract of Prangos ferulacea (L.) Lindle (P.f) on rats' pancreas structure changes and diabetic treatment after streptozotocin injection. Materials and Methods: In this research forty male Wistar rats with body weights of 100±20 gram, were randomly divided into 5 groups with 8 rats per each group. Diabetes was induced in rats b...

In pancreatic survey, quantitative and morphological characteristics could be fundamental variables for the evaluation of some structures. The aim of this study was the application of stereological methods for estimation of quantitative parameters and morphological evaluation of the pancreas in chickens. Ten adult male and ten adult female native chickens were used in this study. Routine tissue...

It is important for our understanding of the pancreatic islets to study whether new islets are able to form in the intact pancreas. We developed a new method to determine the total number and the mean volume of the pancreatic islets, and we used this method to study the expansion of the islet mass in ob/ob mice (n = 8), using ob/+ mice (n = 8) as controls. The total islet volume was increased b...

Grafting of microencapsulated pancreatic islets has been proposed as an alternative to exogenous insulin for the treatment type 1 diabetes mellitus. Microencapsulated are protected from direct contact with immune cells and larger immune-active molecules such immunoglobulins. Unfortunately, many islet in microcapsules lost immediate period after transplantation due early host response limiting l...

Xu J, Zhang L, Chou A, Allaby T, Bélanger G, Radziuk J, Jasmin BJ, Miki T, Seino S, Renaud J-M. KATP channel-deficient pancreatic -cells are streptozotocin resistant because of lower GLUT2 activity. Am J Physiol Endocrinol Metab 294: E326–E335, 2008. First published November 27, 2007; doi:10.1152/ajpendo.00296.2007.—In wild-type mice, a single injection of streptozotocin (STZ, 200 mg/kg body wt...

The lysosomal enzyme iduronate-2-sulfatase (IDS) is expressed in pancreatic islets and is responsible for degradation of proteoglycans, such as perlecan and dermatan sulfate. To determine the role of IDS in islets, expression and regulation of the gene and localization of the enzyme were investigated in mouse pancreatic islets and clonal cells. The Ids gene was expressed in mouse islets and bet...

Previous studies have provided evidence for the transcripts of Cx43 and Cx45 within pancreatic islets. As of yet, however, it has proven difficult to unambiguously demonstrate the expression of these proteins by islet cells. We have investigated whether Cx36, a new connexin species recently identified in mammalian brain and retina, may also be expressed in pancreatic islets. Using probes that p...

BACKGROUND The unique mechanism of dithizone action in the interior of the viable pancreatic islet suggests the possible development of a specific radiopharmaceutical that may have a potential clinical application in the diagnosis of the pancreatic organ allografts or islets rejection. The radiodiagnostic properties of the newly developed radioactive analogue of dithizone, i.e. Dithizone-[(131)...

Protein expression of an antiaging gene, Klotho, was depleted in pancreatic islets in patients with type 2 diabetes mellitus (T2DM) and in db/db mice, an animal model of T2DM. The objective of this study was to investigate whether in vivo expression of Klotho would preserve pancreatic β-cell function in db/db mice. We report for the first time that β-cell-specific expression of Klotho attenuate...

Aim. The study is aimed at describing pancreatic islets as one of the SARS-CoV-2 targets. Materials and methods. object was pancreas. involved histological staining. Results discussion. autopsy revealed signs typical bilateral viral interstitial pneumonia. Histological examination alveoli with disatelectasis, intra-alveolar edema, hyaline membranes in a part alveoli. pancreas showed hemorrhages...