results coincubation of islets with vitamin d (10 nm) and 11.1 mm glucose increased islet insulin release (37.27 ± 3.75 vs. 24.64 ± 2.83 ng/islet/24 hours; p < 0.05), while vitamin d (1 and 10 nm) decreased insulin release in the presence of 16.7 mm glucose (21.14 ± 3.58 and 18.65 ± 3.84 vs. 37.71 ± 4.63 ng/ islet/24 hours; p < 0.05). islets preincubation with vitamin d (1 and 10 nm) increased ...

in an effort to evaluate the hypoglycemic activity of t. polium, the crude extract was administered orally to a group of streptozotocin induced diabetic rats for 6 consecutive weeks. significant decrease in blood glucose by 64%, total bilirubin by 35%, glutamate oxaloacetate transferase by 48% and glutamate pyruvate transferase by 30% was observed compared to untreated diabetic rats. however, t...

The aim of the present study was to investigate the effect of gender on the distribution of pancreatic islets in native chicken. Ten adult male and ten adult female Isfahan native chickens were used in this experiment. Results showed a distinct sexual dimorphism in the native chicken pancreas which depends upon the various fractions of the pancreatic lobes, which were occupied by alpha, beta an...

Objective(s): Arsenic, a toxic metal in drinking water and butyric acid (BA) is a free fatty acid found in many foods. These two can induce oxidative stress in some tissues. The present study investigated the protective effect of metformin against toxicity induced by Arsenic (As) and BA in isolated mice liver mitochondria and pancreatic islets. Materials and Methods: In this study, liver mitoch...

in pancreatic survey, quantitative and morphological characteristics could be fundamental variables for the evaluation of some structures. the aim of this study was the application of stereological methods for estimation of quantitative parameters and morphological evaluation of the pancreas in chickens. ten adult male and ten adult female native chickens were used in this study. routine tissue...

the aim of the present study was to investigate the effect of gender on the distribution of pancreatic islets in native chicken. ten adult male and ten adult female isfahan native chickens were used in this experiment. results showed a distinct sexual dimorphism in the native chicken pancreas which depends upon the various fractions of the pancreatic lobes, which were occupied by alpha, beta an...

abstract reactive oxygen species and oxidative stress impair β-cell function and reduce insulin secretion. it has been shown that progesterone and cilostazol possess antioxidant properties. the present study was aimed to investigate in vitro pretreatment effect of progesterone and cilostazol on insulin secretion as well as their protective effects against hydrogen peroxide-induced oxidative str...

objective(s): ghrelin is a peptide hormone that has been shown to have numerous central and peripheral effects. the central effects including gh secretion, food intake, and energy homeostasis are partly mediated by kiss1- kissr signaling pathway. ghrelin and its receptor are also expressed in the pancreatic islets. ghrelin is one of the key metabolic factors controlling insulin secretion from t...