A substantial portion of schizophrenia patients with obsessive compulsive disorder fail to respond to regimen of antipsychotic and selective serotonin reuptake inhibitor. Herein, we report a schizophrenic patient who, after being switched from escitalopram to milnacipran, showed a rapid improvement of his debilitating OCD. A 23-year-old unemployed single man had been diagnosed with schizophreni...

A significant proportion of patients with schizophrenia receiving clozapine remain with partial response. In this group of patients findings regarding addition of various psychotropics to ongoing clozapine treatment for augmentation are controversial. In this review, literature regarding the efficacy and safety of adjunctive agents in clozapine resistant schizophrenic patients is examined. Augm...

To determine the role of NK cells in regulation of tissue growth, the phenotype and function of liver-resident NK cells were studied after 70% partial hepatectomy in rats. The process of liver regeneration was generally completed by day 14. In contrast, the number of liver-resident NK cells (NKR-P1bright) was restored as early as day 3 after partial hepatectomy. However, spontaneous functions o...

BACKGROUND AND PURPOSE Collateral flow augmentation using partial aortic occlusion may improve cerebral perfusion in acute stroke. We assessed the safety and feasibility of partial aortic occlusion immediately after intravenous tissue plasminogen activator. METHODS We conducted an open-label pilot study of partial aortic occlusion after thrombolysis. The primary end point was all serious adve...

spherical equivalent (se) has not been linked to increased cardiovascular morbidity. methods: 132 hungarian twins (age 43.3±16.9 years) underwent refraction measurements (huvitz mrk-3100 premium autorefractokeratometer) and oscillometry (tensiomed arteriograph). results: heritability analysis indicated major role for genetic components in the presence of right and left se (82.7%, 95%ci, 62.9 to...

Primary hypersomnia, a rare clinical syndrome, was diagnosed in a 14-year-old boy. The syndrome showed partial response to high dose fluoxetine therapy (120 mg/day) which recruited insomnia, an adverse effect of the drug, for therapeutic purposes. Response was enhanced with intermittent methylphenidate in association with a lower dose of fluoxetine. A possible pharmacokinetic interaction develo...

Background According to the American Psychiatric Association practice guidelines, if a patient with Major Depressive Disorder (MDD) has not responded or achieved only a partial response after 4-8 weeks of therapy, a dose change, switch to a new drug, or augmentation therapy is recommended [1]. Combined use of standard antidepressants with dopaminergic agents and psychostimulants can lead to acc...