Edaravone has been shown to reduce ischemia/reperfusion-induced peripheral nerve injury. However, the therapeutic effect of edaravone on peripheral nerve injury caused by mechanical factors is unknown. In the present study, we established a peripheral nerve injury model by crushing the sciatic nerve using hemostatic forceps, and then administered edaravone 3 mg/kg intraperitoneally. The sciatic...

After peripheral nerve injury, nociceptive afferents acquire an abnormal excitability to adrenergic agents, possibly due to an enhanced expression of α1-adrenoceptors (α1-ARs) on these nerve fibres. To investigate this in the present study, changes in α1-AR expression on nerve fibres in the skin and sciatic nerve trunk were assessed using immunohistochemistry in an animal model of neuropathic p...

conclusion vr reconstruction for both single-direction images and sushi using dti25 raw data provides excellent 3d displays of the peripheral nerves in the wrist region. sushi post-processing is a useful denoising tool because it automatically reduces the majority of isotropic object noise. results single-direction vr reconstruction clearly showed the nerves for both dti6 and dti25 but with obv...

Peripheral nerve injury is a common clinical problem because the dysfunction of distal limb seriously affects patients’ quality of life, and it results in a huge social and economic burden.[1] Repair of peripheral nerve injury is a very complex pathological process. Due to slow nerve regeneration, Wallerian degeneration of nerve stump, tissue adhesion, atrophy of muscles and motor end plates an...

TOPICS COVERED IN THIS CHAPTER Peripheral pain mechanisms Primary afferent nociceptors Visceral afferents Sympathetic nervous system Peripheral sensitisation/inflammation Role of nerve growth factor in peripheral sensitisation Silent nociceptors Peripheral nerve injury Clinical implications for peripheral analgesic action Dorsal horn mechanisms Termination sites of primary afferents Outputs fro...

Introduction: Glycogen Synthase Kinase-3β (GSK-3β) participates in several signaling pathways and plays a crucial role in neurodegenerative diseases, inflammation, and neuropathic pain. The ratio of phosphorylated GSK-3β over total GSK-3β (p-GSK-3β/t-GSK-3β) is reduced following nerve injury. Apoptosis is a hallmark of many neuronal dysfunctions in the context of neuropathic pain. Thus, this st...

Peripheral nerve injury may result in injury without gaps or injury with gaps between nerve stumps. In the presence of a nerve defect, the placement of an autologous nerve graft is the current gold standard for nerve restoration. The clinical employment of tubes as an alternative to autogenous nerve grafts is mainly justified by the limited availability of donor tissue for nerve autografts and ...