OBJECTIVE To determine whether use of intrapartum Pethidine pain analgesia increases the risk for substance use disorder in adult offspring. DESIGN Analysis of data from a cohort study. SETTING Academic hospital in Leiden, the Netherlands. PARTICIPANTS 133 cases and 164 control individuals, aged 18-20 years at follow-up. MAIN OUTCOME MEASURE Incidence of substance use disorder or use of...

OBJECTIVE To compare the analgesic efficacy and side effects of ketorolac with pethidine in a day care procedure. STUDY DESIGN Single dose, double blind, case matched study. METHODS Sixty patients were divided into group A and group B, who received either ketorolac 30 mg or Pethidine 0.8 mg/kg ( both IN ) respectively at the time of induction of general anaesthesia. Patients were assessed i...

The effects on biliary pressure of pentazocine, morphine, pethidine, and phenazocine were compared by direct measurement through a ;T' tube after choledochotomy. In two within-patient comparisons, the mean increases in biliary pressure following intramuscular morphine were significantly greater than those following pentazocine. When pethidine and phenazocine were compared with pentazocine, the ...

Introduction: The pain relief effect of Paracetamol, as a safe analgesic drug in labor, compared to Pethidine, as a well-known analgesic drug, need to be more evaluated. Objective: This study aims to compare the effects of Paracetamol and Pethidine on the first-stage labor pain relief and neonatal and maternal complications. Materials and Methods: This single-blind, parallel group, randomized...

BACKGROUND The commonest opioid used for pain relief in labour is pethidine (meperidine); however, its effectiveness has long been challenged and the drug has known side effects including maternal sedation, nausea and potential transfer across the placenta to the foetus. Over a third of women receiving pethidine require an epidural due to inadequate pain relief. Epidural analgesia increases the...

Introduction: Shivering after anaesthesia and surgery is a common complication. Different methods are used for control of shivering in the recovery room. The opioids such as pethidine are very common in shivering control. Pethidine can be induced apnea, respiratory depression and nausea &vomiting. The respiratory rate and spo2 can lead to more rapid diagnosis and treatment of serious hypoxemia ...

OBJECTIVE Intramuscular (i.m.) pethidine is used worldwide for labour analgesia and i.m. diamorphine usage has increased in the UK in the last 15 years. This trial aims to ascertain the relative efficacy and adverse effects of diamorphine and pethidine for labour pain. DESIGN Prospective, parallel-arm randomised controlled trial with blinding of participants, care-givers and outcome assessors...

BACKGROUND Appropriate pain management is needed during the post-partum hospitalization period for preventing cesarean section (CS) related complications. Protocols of post-partum pain management should be planned based on the facilities of each center or region. The aim of current study was to compare the analgesic efficacy of oral methadone and intra muscular (IM) pethidine which the latter w...