نتایج جستجو برای: pharmacogenomic
تعداد نتایج: 2060 فیلتر نتایج به سال:
This PharmGKB summary briefly discusses the CYP2C19 gene and current understanding of its function, regulation, and pharmacogenomic relevance.
Pharmacogenomics is one of the first clinical applications of the postgenomic era. It promises personalized medicine rather than the established "one size fits all" approach to drugs and dosages. The expected reduction in trial and error should ultimately lead to more efficient and safer drug therapy. In recent years, commercially available pharmacogenomic tests have been approved by the Food a...
Pre-emptive pharmacogenetic (PGx) testing combined with clinical decision support is a promising new strategy for making pharmacotherapy safer and more effective. To estimate the number of patients whose therapies could be guided by this approach, we analysed claims data for patients in Austria in the years 2006 and 2007. We calculated the number of patients receiving one or several drugs for w...
We evaluated the clinical validity of a combinatorial pharmacogenomic test and single-gene Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines against patient outcomes medication blood levels to assess their ability inform prescribing in major depressive disorder (MDD). This is secondary analysis Genomics Used Improve DEpression Decisions (GUIDED) randomized-controlled trial, ...
OBJECTIVE The objective was to evaluate the potential benefit of an integrated, five-gene pharmacogenomic test and interpretive report (GeneSight) for the management of psychotropic medications used to treat major depression in an outpatient psychiatric practice. METHODS The open-label study was divided into two groups. In the first (unguided) group (n = 113), pharmacogenomic information was ...
In 2013 we published an analysis demonstrating that drug response data and gene-drug associations reported in two independent large-scale pharmacogenomic screens, Genomics of Drug Sensitivity in Cancer (GDSC) and Cancer Cell Line Encyclopedia (CCLE), were inconsistent. The GDSC and CCLE investigators recently reported that their respective studies exhibit reasonable agreement and yield similar ...
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