introduction: interaction between drugs represents a major clinical concern for health care professionals and their patients. patients affected by both type 2 diabetes and epilepsy may be prescribed pioglitazone and an anti-epileptic drug such as phenytoin  concurrently. the aim of this study was to consider the interaction of pioglitazone with phenytoin in an experimental model. according to t...

background: osteoarthritis is a disabling musculoskeletal disease with no definite treatment. this study compared the effect of platelet-rich plasma (prp) and transcutaneous electrical nerve stimulation (tens) plus exercise in the treatment of patients with knee joint osteoarthritis.   methods : 54 eligible patients with knee osteoarthritis were randomly allocated into two groups. (irct20121106...

acute coronary syndrome is the leading cause of mortality worldwide. for prompt diagnosis and management of this disease, several biomarkers have been utilized. recently microrna which are suggestive of tissue damage and some are cardiospecific are paid special attention and might help in dearly diagnosis of this disease and furthermore help in preventing the resultant mortality. in this review...

in previous studies, mebudipine, a dihydropyridine calcium channel blocker, showed a considerable potential to be used in cardiovascular diseases. the aim of the current study was to develop a valid method using reversed-phase high performance liquid chromatography coupled with electrospray ionization mass spectrometry to assay mebudipine in the human plasma. separation was achieved on a zorbax...

a validated hplc method was developed to determine doxorubicin concentration in a small volume of rat plasma (60 µl) with convenient fluorescence detection. sample preparation includes a simple one-step liquid-liquid extraction using minimum amount of organic solvent, with extraction recoveries more than 95%. the analysis was accomplished using perfectsil c18 column maintained at 35 °c and a mo...

the in vitro dissolution of plasma-sprayed hydroxyapatite (pha) coatings with different characteristics, produced by various spraying conditions, in a tris-buffered solution at ph 7.4 was experimentally studied through the measurement of calcium ions release with inductively coupled plasma atomic emission spectroscopy (icp-aes), and then modeled. three coating characteristics, the crystallinity...

licorice is obtained from glycyrrhiza glabra (g. glabra) in iran. glycyrrhizin is the main constituent of g. glabra and has several pharmacological effects. it is hydrolyzed to glycyrrhetic acid (ga) in the intestine after oral administration. in this study, a novel hplc method was used to determine the concentration of ga in rat plasma after oral administration of licorice aqueous extract. the...