Essential fatty acids (EFA) are a group of unsaturated fatty acids which are not produced in humans, but are necessary for the proper functioning of the human body. It is mostly found in vegetable oils, seeds and nuts. They have shown diverse medicinal properties and potential beneficial effects on diseases such as cancer, insulin resistance, skin permeability, cardiovascular disease and depres...

A total of 28 lapachol-related naphthoquinones with four different scaffolds were synthesized and spectroscopically characterized. In vitro antiplasmodial activity was assayed against the chloroquine-resistant Plasmodium falciparum W2 strain by the parasite lactate dehydrogenase (pLDH) method. Cytotoxicity against Hep G2A16 cell was determined by the MTT assay. All compounds disclosed higher in...

BACKGROUND & OBJECTIVES The present study was undertaken to find out a new easy method in the diagnosis of malaria by centrifuged buffy coat smear, which was found to be a feasible and reasonable procedure. METHODS Blood samples collected from 120 patients suspected of malaria were subjected to all three diagnostic modalities-peripheral blood smear (PS), centrifuged buffy coat smear (CBCS) an...

Hierarchical nanoarchitecture and porous structure can both provide advantages for improving the electrochemical performance in energy storage electrodes. Here we report a novel strategy to synthesize new electrode materials, hierarchical Co-based porous layered double hydroxide (PLDH) arrays derived via alkali etching from Co(OH)2@CoAl LDH nanoarrays. This structure not only has the benefits o...

1. The screening for potential anti-malaria properties by bioassay guided fractionations. The biological properties were carried out using the plasmodium lactate dehydrogenase assay (pLDH) (Makler, 1993). 2. The harmful effect of the extract was determined by the MTT assay (Mossman, 1983). 3. The extracts were tested for its efficacy in animal model using rodent malaria parasite, P. berghei usi...

1. The screening for potential anti-malaria properties by bioassay guided fractionations. The biological properties were carried out using the plasmodium lactate dehydrogenase assay (pLDH) (Makler, 1993). 2. The harmful effect of the extract was determined by the MTT assay (Mossman, 1983). 3. The extracts were tested for its efficacy in animal model using rodent malaria parasite, P. berghei usi...

BACKGROUND The World Health Organization (WHO) considers early and rapid diagnosis as one of the strategies to control malaria. This study compared the performance of Quantitative Buffy Coat (QBC) test and the Plasmodium lactate dehydrogenase (pLDH) rapid diagnostic test (RDT) with microscopy as the gold standard. MATERIALS AND METHODS The study involved children ages 0-5 years who presented ...