Poly(N-vinyl pyrrolidone) (PVP), poly(2-methyl-2-oxazoline) (PMOZ), poly(2-ethyl-2-oxazoline) (PEOZ), poly(2-n-propyl-2-oxazoline) (PnPOZ), and poly(2-isopropyl-2-oxazoline) (PiPOZ) were used to prepare solid dispersions with ibuprofen (IB), a model poorly-water soluble drug. Dispersions, prepared by solvent evaporation, investigated using powder X-ray diffractometry, differential scanning calo...

conclusions midazolam could be used as a safe and effective drug for conscious sedation, general anaesthetic premedication and the treatment of seizures during dental treatment. however, further research on paediatric patients would be beneficial. evidence acquisition to conduct this review of the literature, pub-med and scopus were searched using the following terms: midazolam, oral, transmuco...

     In this study, microspheres containing estradiol valerate were prepared by solvent evaporation method using poly (glycolide-co-lactide) (PLGA 50:50) and poly (lactide). The effect of different process variables such as polymer type, drugpolymer ratio, stirring rate, volume of internal phase and temperature of external phase on the morphology, particle size distribution, encapsulation effic...

This paper describes an attempt to capture individual and social characteristics of polydrug use in a generic agent-based model called SimUse. We consider poly-drug use and its social context as a complex adaptive system and use a generative framework to create an iterative dialogue between observations, theoretical constructs and computer simulations. This iterative process allows us, through ...

The current study examined the relationship between poly-substance use and sex trade among 343 black South African substance users recruited from the Pretoria region between 2002 and 2006 (57% males; mean age 24 years). The assessment comprised a HIV-risk behavior interview, urinalysis to confirm self-report of drug use, and an HIV test. Logistic regression analyses indicated poly-substance use...

Considering the largely chiral nature of biological systems, there is interest in drug delivery systems. Here, we investigate for first time polymer micelles based on poly(2-oxazoline) (POx) ABA-type triblock copolymers with and racemic hydrophobic blocks formulation achiral drugs. Specifically, poly(2-ethyl-4-ethyl-2-oxazoline) (pEtEtOx) poly(2-propyl-4-methyl-2-oxazoline) (pPrMeOx) were used ...

Cyclodextrins (CDs) have been extensively studied as drug delivery carriers through host–guest interactions. CD-based poly(pseudo)rotaxanes, which are composed of one or more CD rings threading on the polymer chain with or without bulky groups (or stoppers), have attracted great interest in the development of supramolecular biomaterials. Poly(ethylene oxide) (PEO) is a water-soluble, biocompati...

background: intimate partner violence (ipv) and risky sexual behaviors are serious and overlapping public health problems that disproportionately affect drug-involved women. despite the fact that drug-using women experience extensive ipv, to date, no studies have investigated the association of ipv and risky sexual behaviors among drug-using women in iran. methods : drug-using women (n =120) we...

ISSN:0975-1459 The development of alginate beads as a drug carrier system is considered to be more attractive because of its biocompatibility, mucoadhesive property, and its ability to deliver drug particularly in the intestinal pH. The preparation of alginate beads by ionic gelation method avoids the usage of toxic organic solvents and considered to be relatively economical method. However its...