Preclinical in vitro and in vivo studies demonstrate potent effects of pomegranate preparations in cancer cell lines and animal models with chemically induced cancers. We have carried out one systematic review of the effectiveness of pomegranate products in the treatment of cancer and another on their safety. The PubMed search provided 162 references for pomegranate and cancer and 122 reference...

The present study was conducted to evaluate wound induced in rabbit skin by using alcohols and aqueous extracts of pomegranate seeds. Total flavonoids concentration were estimated high performance liquid chromatography (HPLC). highest recorded ethanol extract. Acute inflammation laboratory animals (rabbits) injecting 0.1mL 2.5% formalin inside the incision. Aqueous seeds an anti-inflammatory he...

Pomegranate fruit is to rich in phenolic compounds and antioxidant properties can show difference the composition according cultivars, part of fruit, environmental conditions analysis method. Therefore, aim present study was analyse compare chemical from different parts Valenciana Wonderful pomegranate cultivars. The fruits were separated into aril, peel, membrane seeds manually analysed by com...

Unpasteurized fruit juice has been implicated in outbreaks of Escherichia coli O157:H7 (E. coli O157:H7). Meanwhile, certain fruit, such as pomegranate, contains antimicrobial components. The objective of this study was to investigate the survival and growth characteristics of E. coli O157:H7 on pomegranate juice in laboratory medium and in pomegranate-carrot and pomegranate-apple blend juices ...

In this study, we investigated whether pomegranate juice could inhibit CYP2C9 activity. The ability of pomegranate juice to inhibit the diclofenac 4'-hydroxylase activity of human CYP2C9 was examined using human liver microsomes. Pomegranate juice was shown to be a potent inhibitor of human CYP2C9. The addition of 25 microl (5% v/v) of pomegranate juice resulted in almost complete inhibition of...

The health benefits associated with pomegranate juice have led to the development of pomegranate extracts as botanical dietary supplements. Pomegranates contain hydrolyzable tannins in the form of punicalagins and punicalin as well as tannin-based complex oligomers that account for much of the antioxidant activity in juice. The content of ellagic acid has been used to standardize most pomegrana...

Two exploratory clinical studies investigating proprietary pomegranate products showed a trend of effectiveness in increasing prostate-specific antigen doubling time in patients with prostate cancer. A recent clinical study did not support these results. We therefore analysed a lot of the marketed pomegranate blend for co-active pomegranate compounds. The high-performance liquid chromatography ...

Background: High level of blood cholesterol can cause diseases such as atherosclerosis, high blood pressure, cardiovascular diseases, and increase the chance of apoplexy and fatty liver. Unsaturated fatty acids play important roles in preventing cardiovascular diseases because they decrease total cholesterols and LDL-C in the blood. Objective: The study investigates some sterol compounds of Ira...

The pomegranate, Punica granatum L., has been the subject of current interest as a medicinal agent with wide-ranging therapeutic indications. In the present study, pomegranate ethanolic seed and hull extracts were tested, in comparison with a commercial sample, for the inhibition of aldose reductase, an enzyme involved in the etiology of diabetic complications. In vitro inhibition of rat lens a...