Brown adipose tissue (BAT) represents a promising agent to ameliorate obesity and other metabolic disorders. However, the abundance of BAT decreases with age and BAT paucity is a common feature of obese subjects. As brown adipocytes and myoblasts share a common Myf5 lineage origin, elucidating the molecular mechanisms underlying the fate choices of brown adipocytes versus myoblasts may lead to ...

Acquired molecular abnormalities (mutations or chromosomal translocations) of the RUNX1 transcription factor gene are frequent in acute myeloblastic leukemias (AMLs) and in therapy-related myelodysplastic syndromes, but rarely in acute lymphoblastic leukemias (ALLs) and chronic myelogenous leukemias (CMLs). Among 18 BCR-ABL+ leukemias presenting acquired trisomy of chromosome 21, we report a hi...

Beige Adipocyte fat is gaining increasing therapeutic interest due to its potential in combating obesity and other non-communicable diseases. By single clone analysis, Tao Nie, Donghai Wu, Hannah Xiaoyan Hui, co-workers discover that androgen receptor (AR) turns out be a highly potent transcription factor suppression of PRDM16, the key molecular switch beige fat. The article number 2300070 prov...

Rationale: Understanding the mechanisms that regulate arterial flow recovery is important to design treatment options for peripheral artery disease patients ineligible invasive revascularization. Transcriptional orchestrators of this process represent an appealing target design. We previously identified Prdm (positive regulatory domain-containing protein) 16 as arterial-specific endothelial tra...