نتایج جستجو برای: prdm16

تعداد نتایج: 242  

2017
Sergio Groman-Lupa Joseph Adewumi Ko Uoon Park Joseph A. Brzezinski

Purpose Retinal ganglion cells (RGC) can be categorized into roughly 30 distinct subtypes. How these subtypes develop is poorly understood, in part because few unique subtype markers have been characterized. We tested whether the Prdm16 transcription factor is expressed by RGCs as a class or within particular ganglion cell subtypes. Methods Embryonic and mature retinal sections and flatmount ...

Journal: :Oncotarget 2016
Qianqian Lei Xiaoping Liu Haijuan Fu Yingnan Sun Liping Wang Gang Xu Wei Wang Zhibin Yu Changhong Liu Peiyao Li Jianbo Feng Guiyuan Li Minghua Wu

Our previous report identified PR domain containing 16 (PRDM16), a member of the PR-domain gene family, as a new methylation associated gene in astrocytoma cells. This previous study also reported that miR-101 is a tumor suppressor in glioma. The present study confirms that PRDM16 is a hypomethylated gene that can be overexpressed in astrocytoma patients and demonstrates that the hypomethylatio...

Journal: :Gene 2015
Xiao Li Jinquan Wang Zheng Jiang Feng Guo Paul D Soloway Ruqian Zhao

The positive regulatory domain containing 16 (PRDM16) is commonly regarded as a "switch" controlling the transdifferentiation of myoblasts to brown adipocytes. The N-positive regulatory (PR) domain, which is highly homologous to SET domain, is a characteristic structure for the PRDM family. Many SET domain containing proteins and several PRDM members have been found to possess histone methyltra...

2011
Francesca Aguilo Serine Avagyan Amy Labar Ana Sevilla Dung-Fang Lee Parameet Kumar Ihor R. Lemischka Betty Y. Zhou Hans-Willem Snoeck

Fetal liver and adult bone marrow hematopoietic stem cells (HSCs) renew or differentiate into committed progenitors to generate all blood cells. PRDM16 is involved in human leukemic translocations and is expressed highly in some karyotypically normal acute myeloblastic leukemias. As many genes involved in leukemogenic fusions play a role in normal hematopoiesis, we analyzed the role of Prdm16 i...

Journal: :Blood 2011
Francesca Aguilo Serine Avagyan Amy Labar Ana Sevilla Dung-Fang Lee Parameet Kumar Ihor R Lemischka Betty Y Zhou Hans-Willem Snoeck

Fetal liver and adult bone marrow hematopoietic stem cells (HSCs) renew or differentiate into committed progenitors to generate all blood cells. PRDM16 is involved in human leukemic translocations and is expressed highly in some karyotypically normal acute myeloblastic leukemias. As many genes involved in leukemogenic fusions play a role in normal hematopoiesis, we analyzed the role of Prdm16 i...

Journal: :Temperature 2015
Jeff Ishibashi Patrick Seale

The PR-domain containing 16 (Prdm16) protein is a powerful inducer of the thermogenic phenotype in fat cells. In both developmental (brown) and induced (beige) thermogenic adipose tissue, Prdm16 has a critical role in maintaining proper tissue structure and function. It has roles throughout the course of differentiation, beginning with lineage determination activity in precursor cells, and cont...

Journal: :American journal of human genetics 2013
Anne-Karin Arndt Sebastian Schafer Jorg-Detlef Drenckhahn M Khaled Sabeh Eva R Plovie Almuth Caliebe Eva Klopocki Gabriel Musso Andreas A Werdich Hermann Kalwa Matthias Heinig Robert F Padera Katharina Wassilew Julia Bluhm Christine Harnack Janine Martitz Paul J Barton Matthias Greutmann Felix Berger Norbert Hubner Reiner Siebert Hans-Heiner Kramer Stuart A Cook Calum A MacRae Sabine Klaassen

Deletion 1p36 syndrome is recognized as the most common terminal deletion syndrome. Here, we describe the loss of a gene within the deletion that is responsible for the cardiomyopathy associated with monosomy 1p36, and we confirm its role in nonsyndromic left ventricular noncompaction cardiomyopathy (LVNC) and dilated cardiomyopathy (DCM). With our own data and publically available data from ar...

Journal: :Trends in endocrinology and metabolism: TEM 2016
Jingyi Chi Paul Cohen

The PRDM [PRDI-BFI (positive regulatory domain I-binding factor 1) and RIZ1 (retinoblastoma protein-interacting zinc finger gene 1) homologous domain containing] protein family is involved in a spectrum of biological processes including cell fate determination and development. These proteins regulate transcription through intrinsic chromatin-modifying activity or by complexing with histone-modi...

Journal: :The Journal of clinical investigation 2011
Patrick Seale Heather M Conroe Jennifer Estall Shingo Kajimura Andrea Frontini Jeff Ishibashi Paul Cohen Saverio Cinti Bruce M Spiegelman

The white adipose organ is composed of both subcutaneous and several intra-abdominal depots. Excess abdominal adiposity is a major risk factor for metabolic disease in rodents and humans, while expansion of subcutaneous fat does not carry the same risks. Brown adipose produces heat as a defense against hypothermia and obesity, and the appearance of brown-like adipocytes within white adipose tis...

Journal: :Genes & development 2008
Shingo Kajimura Patrick Seale Takuya Tomaru Hediye Erdjument-Bromage Marcus P Cooper Jorge L Ruas Sherry Chin Paul Tempst Mitchell A Lazar Bruce M Spiegelman

Brown fat is a specialized tissue that can dissipate energy and counteract obesity through a pattern of gene expression that greatly increases mitochondrial content and uncoupled respiration. PRDM16 is a zinc-finger protein that controls brown fat determination by stimulating brown fat-selective gene expression, while suppressing the expression of genes selective for white fat cells. To determi...

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