Abstract Aim Hepatocellular carcinoma (HCC) is a primary liver cancer that usually develops in background of chronic disease and prolonged inflammation. A major contributor the complex molecular pathogenesis HCC highly intertwined cross-talk between tumor surrounding stromal cells, such as hepatic stellate endothelial macrophages other immune cells. These tumor-stroma interactions actively fuel...

background: the present study was designed to evaluate the homing potential of mouse embryonic stem cells (esc) treated with erythropoietin (epo) in hematopoietic organs such as spleen and liver after transplantation using morphological and immuno-histochemical techniques. methods: day-four embryoid body (eb)-derived cells were dissociated and re-plated in medium in the presence and absence of ...

objective(s): with the advent of nanotechnology, significant progress has been made in the area of nanoscale materials such as nanosilver (ag-nps). these nanoparticles have a wide range of applications and been used for antimicrobial purposes for more than a century. however, little attention has been paid to the toxicity of nanosilver wound dressing. this study was designed to investigate the ...

Abstract Tumor associated immunosuppressive cells limit the efficacy of CAR T against solid tumors. To alter immunosuppression in tumor microenvironment, were armored with an IL-2 superkine (Super2) and alarmin IL-33 adoptively transferred into immunocompetent mice established primary or metastatic B16F10 melanoma intradermal MC38 colon carcinoma. We show that Super2-IL-33 universally promoted ...

Ursodeoxycholic acid (UDCA) is the primary treatment for biliary cholangitis (PBC), but its mechanism of action remains unclear. Studies suggest that UDCA enhances NF erythroid 2-related factor 2 (NFE2L2) expression and interaction between IFN-γ C-X3-C motif chemokine ligand 1 (CX3CL1) facilitates inflammation in PBC. Therefore, we examined effects on CX3CL1 vitro vivo PBC models such as human ...

objective(s):fuzheng huayu recipe (fzhy) exerts significant protective effects against liver fibrosis by strengthening the body’s resistance and removing blood stasis. however, the molecular mechanisms through which fzhy affects liver fibrosis are still unclear. in this study, we examined the expression levels of factors involved in the inhibitor κb kinase-β (ikk-β)/nuclear factor-κb (nf-κb) an...

Objective(s): With the advent of nanotechnology, significant progress has been made in the area of nanoscale materials such as nanosilver (Ag-Nps). These nanoparticles have a wide range of applications and been used for antimicrobial purposes for more than a century. However, little attention has been paid to the toxicity of nanosilver wound dressing. This study was designed to investigate the ...

Background: The present study was designed to evaluate the homing potential of mouse embryonic stem cells (ESC) treated with erythropoietin (EPO) in hematopoietic organs such as spleen and liver after transplantation using morphological and immuno-histochemical techniques. Methods: Day-four embryoid body (EB)-derived cells were dissociated and re-plated in medium in the presence and absence of ...