Tabby is a mouse mutant characterized by deficient development of the ectodermal organs: teeth, hair, and a subset of glands. Ectodysplasin, the protein encoded by the Tabby gene, was recently identified as a novel TNF-like transmembrane protein but little is known about its function. We have examined the Tabby tooth phenotype in detail by analysis of the adult and embryonic teeth. Tabby first ...

Mammalian tooth crowns have precise functional requirements but cannot be substantially remodeled after eruption. In developing teeth, epithelial signaling centers, the enamel knots, form at future cusp positions and are the first signs of cusp patterns that distinguish species. We report that ectodin, a secreted bone morphogenetic protein (BMP) inhibitor, is expressed as a "negative" image of ...

BACKGROUND AND AIM: Trauma is a common problem among blindness and visually impaired children. The purpose of the current study was the assessment of the prevalence of traumatic dental injuries and the enamel defects resulted from these injuries among 6-12 years old blind children in comparison to the sighted children in Kerman. METHODS: In this cross-sectional study, sample size was considered...

AIM To assess the prevalence of molar incisor hypomineralisation (MIH) in children in Slovenia and explore the relationship between MIH defects and caries in the primary and permanent dentition, and tooth- and surface-specific associations between MIH defects and caries on first permanent molars (FPM). MATERIALS AND METHODS The study population was comprised of 558 children aged 6.011.5 years...

trauma to primary teeth can lead to devastating sequels in development of permanent successors. the disturbance may range from enamel hypoplasia and/or hypo-calcification to arrest of dental bud development. crown dilaceration of permanent teeth is one of the consequences of trauma to deciduous teeth mainly due to intrusion or avulsion. this report presents a mandibular central incisor with dil...

AIM To assess the prevalence and to investigate the pathogenetic mechanisms of dental and periodontal lesions in children with X-linked hypophosphatemic rickets (XLH) examined at diagnosis or during treatment. METHODS Nine children with XLH (age 7.2 +/- 3.3 years) were enrolled in the study (at diagnosis, n = 2; during treatment with oral inorganic phosphate salts combined with 1,25-dihydroxy...

Introduction: This study investigated the sealing ability of three different adhesives in primary bovine teeth. Methods: Facial and lingual class V cavities were prepared half in enamel and half in cementum, in 48 bovine primary mandibular incisors and randomly divided into three groups and each group divided to two subgroups. The tested adhesives were XPBond (XP), ClearfilS3 Bond (S3), and Xen...

Enamel formation (amelogenesis) in the human dentition begins in utero. The process has been investigated widely in the primary dentition in animals, and to a much lesser extent in humans. Studies have confirmed that amelogenesis occurs in distinct stages. 1 Each of these stages may be affected by extreme systemic physiological changes with hypoplasia, hypomineralization, or opacities of enamel...

To study human evolution [4], researchers sometimes use microstructures found in human teeth and their knowledge of the processes by which those structures grow. Human fetuses begin to develop teeth in utero. As teeth grow, they form a hard outer substance, called enamel, through a process called amelogenesis. During amelogenesis, incremental layers of enamel form in a Circadian rhythm. This rh...