Procaine amide (Pronestyl) was administered to patients with auricular fibrillation and flutter in an attempt to restore sinus rhythm. Thirteen of 20 patients with auricular fibrillation had sinus rhythm re-established. Several of the patients who were not converted with procaine amide were later restored to sinus rhythm with quinidine. OR MANY YEARS the restoration of sinus rhythm in patients ...

Because of the increase in strains of N. gonorrhoeae relatively resistant to penicillin and the subsequent rise in treatment failures (Gjessing and Odegaard, 1964), we decided to modify our previous treatment of males (one injection of 600,000 units procaine penicillin). Neither repeated smaller doses of procaine penicillin nor administration of a single large dose seemed to give satisfactory r...

In the last few years we have witnessed an increase in the numbers of gonococcal strains which are relatively resistant to penicillin and a subsequent rise in treatment failures. It was therefore considered necessary to find a substitute for, or a modification of, the routine treatment with benzyl procaine penicillin. In a previous paper (Gjessing and Odegaard, 1965), the results of intramuscul...

OBJECTIVE The aim of this study was to assess whether the presence of procaine in crystalloid cardioplegic solution increases myocardial protection at the ultra structural level. METHODS Eighteen patients that underwent aortic valve replacement in the Hospital de Clínicas de Porto Alegre over a 10-month period were studied. They were randomly allocated into two groups: group A--eight patients...

In 22 dogs with ventricular tachycardia accompanying myocardial infarction, Nupercaine hydro-chloride was found to be a potent suppressor of ectopic impulses. When used alone Nupercaine also produced vomiting and convulsive movements. When combined with morphine, vomiting was eliminated , but convulsions still occurred. When combined with phenobarbital sodium or pentobarbital sodium, the ectopi...

BACKGROUND Procaine is a controversial substance which has been used for "antiageing" effects including cognitive improvement for more than 50 years.Preparations which contain procaine as a component are claimed to prevent, reverse and interrupt dementia. Several products are widely promoted and can be purchased "over the counter" outside the US and via the Internet. Procaine preparations are s...