D-glucoside, Fig. 1) is a potent clinical anticancer agent. It is active against several tumors including small lung cancers, lymphoma, leukemia and Karposi’s sarcoma associated with AIDS. It is used as part of the preparatory regimen for bone marrow transplants in patients with advanced hematological malignancies. The mechanism of action of etoposide is unknown but it is a cell-cycle, phasespe...

not only cancer cells but also normal cells. Because these drugs are not specifically selective for cancer cells, patients suffer from adverse side effects due to the loss of healthy cells. Therefore, it is important to reduce such side effects caused by anti-cancer drugs. DNA damage induces signal transduction pathways called checkpoints, which delay cell cycle progression and permit repair of...

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Investigation of baroclinic tides in the northern South China Sea

1Department of Oncology, Wayne State University, Detroit, MI 48201-1379, USA 2Department of Urology, Wayne State University, Detroit, MI 48201, USA 3Department of Medicine, University of Illinois at Chicago, Chicago, IL 60607-4067, USA 4Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7335, USA 5 Integrated Cancer Genomics Division, The Translational G...

Ed. note: Continuing comment on the role of the clinical chemist Icf. Clin. Chem. 23 1961 (1977)1. A major step in rectifying the “disastrous impact” mentioned here was the first Arnold 0. Beckman conference Icf. Clin. Chem. 23, 1379 (1977)1, the proceedings of which will be published by AACC later this year. This conference has received a good deal of praise from the participants, and was evid...