To investigate the effects of quinine on the electroretinograms (ERGs) of children with cerebral malaria (CM), we recruited subjects during a single malaria season in Blantyre, Malawi. Seventy ERG investigations were performed, on 34 children with CM. Time recorded from completion of the most recent quinine infusion was termed "quinine elapsed time" (QET). In a subgroup of 16 children, whole-bl...

The effect of quinine on pyramidal cell intrinsic properties, extracellular potassium transients, and epileptiform activity was studied in vitro using the rat hippocampal slice preparation. Quinine enhanced excitatory post-synaptic potentials and decreased fast- and slow-inhibitory post-synaptic potentials. Quinine reduced the peak potassium rise following tetanic stimulation but did not affect...

Purpose: Nigeria has adopted quinine as the drug of first choice in the treatment of severe malaria and artemether as an alternative therapy. The purpose of this study was to ascertain whether artemether is a comparable alternative to quinine in the management of severe malaria in Nigerian children. Methods: We conducted a randomized prospective study comparing quinine and artemether therapies ...

Quinine is the most common cause of Drug induced thrombotic microangiopathy (DITMA), being the offending drug in 33% of cases. We present a case of DITMA after only a single dose of quinine with no previous history of quinine exposure treated successfully with plasma exchange (PEX), oral corticosteroid followed by mycophenolatemofetil (MMF). The diagnosis was made by the close temporal relation...

CLINICAL PHARMACOLOGY Pharmacokinetics: Absorption: The oral bioavailability of quinine is 76 to 88% in healthy adults. Quinine exposure is higher in patients with malaria than in healthy subjects. After a single oral dose of quinine sulfate, the mean quinine Tmax was longer, and mean AUC and Cmax were higher in patients with uncomplicated P. falciparum malaria than in healthy subjects, as show...

Background: One of the deadliest parasite infections is malaria. A combination quinine sulphate and doxycycline another therapeutic option for malaria that resistant to chloroquine anticipated be able both combat issue anti-malarial medication resistance as well compliance therapy still raging in certain locations Indonesia. Aim: This study will focus on evaluating possibility interaction betwe...