Becquerell has observed that p-rays change yellow phosphorus into red form. Ramsey* and Cameron* have shown that the radium emanation has destruotive and partial synthetic actions upon water, carbon monoxide, carbon dioxide, hydrogen chloride, and ammonia. The decomposing action of radium rays on the lecithin molecule has been observed by Schwara,4 Schaper,& and Werner.6 On the other hand, no s...

Radium-223 dichloride (radium-223) is an important therapeutic option for the treatment of patients with castration-resistant prostate cancer, symptomatic bone metastases, and no visceral disease. The unique mechanism of action of this first-in-class alpha-emitting radiopharmaceutical underlies its favorable safety profile and low incidence of myelosuppression. In the pivotal phase 3 ALpharadin...

The present study was undertaken with a view of determining in a general way the effects of intravenous administration of radium upon the circulation and respiration. The problem was suggested to us by Dr. William J. Gies, under whose guidance a number of researches, dealing with the more extensive question of the action of radium upon animal and vegetable cells, have recently been carried on i...

Radium-223 is a first-in-class alpha particle-emitting radiopharmaceutical approved for the treatment of bone metastatic castration-resistant prostate cancer. Radium-223 is administered intravenously with no requirement for complex shielding and specifically targets areas of bone metastasis. In a randomized placebo-controlled Phase III study, treatment with radium-223 was shown to improve overa...

In this study, the specific activity of natural and artificial radioactive elements was measured for 50 sediment samples collected from throughout Miankaleh wetland in northern Iran on southeastern side Caspian Sea using a High-Purity Germanium detector. Also, radiological parameters hazard indicators due to environmental gamma radiation caused by these nuclei were calculated distribution map R...

In the present work, we determined activity concentrations of ten Medicinal herbs using gamma spectrometry. The radioactivity concentration 226 Ra, 232 Th, 40 K and 137 Cs were 2.82, 0.63, 984.32, 0.28 Bq/kg, respectively. These doses are not hazardous to general public's health. mean values radium equivalent (Raeq), absorbed dose rates (D), annual effective (De) external hazard index (Hex) 79....

OBJECTIVE This open-label, non-randomized, phase I study examined the pharmacokinetics (PK) and radiation dosimetry of a single dose of radium-223 in Japanese patients with castration-resistant prostate cancer (CRPC) and bone metastases. METHODS Six male Japanese patients (mean age 72.5 years, range 65-79 years) with histologically or cytologically confirmed stage IV adenocarcinoma of the pro...

Bone metastases, which are commonly seen in patients with advanced cancers, are a major cause of skeletal events, disability, and death. Radium-223 dichloride (radium-223; Xofigo, formerly Alpharadin), a first-in-class, alpha-emitting radiopharmaceutical that selectively targets bone metastases with high-energy short-range alpha-particles, has been approved for the treatment of patients with ca...

When Nereis eggs are exposed to radiations from a tube of radium emanation, the walls of which absorb all the alpha-rays, the resulting physiological change is produced by rays having a coefficient of absorption of the order of 23.9 cm.(-1) This fact indicates that the physiological effect is due almost exclusively to beta-rays. The gamma-rays alone can produce the reaction. To produce equivale...