background: poor sleep quality (sq) is common among patients after coronary artery bypass graft surgery (cabg). this study attempted to determine the status of sq following an intervention based on the precede-proceed model in patients with poor sq after cabg. methods: this study was a randomized clinical trial. the study sample, including 100 patients referred to the cardiac rehabilitation cli...

Dopamine D2/D3 receptor partial agonists have been suggested as medications for cocaine dependence. The present experiments examined the effect of acute and repeated administration of drugs with varying intrinsic efficacy at D2/D3 receptors on the relative reinforcing strength of cocaine. Use of socially housed cynomolgus monkeys permitted the assessment of whether social status, known to alter...

One strategy in the search for a pharmacotherapy for cocaine abuse and dependence has been to use drugs with a similar mechanism of action as cocaine, or agonist substitution therapy. Research has indicated that cocaine’s behavioral effects are primarily a result of its blockade of the dopamine (DA), serotonin (5-HT) and norepinephrine (NE) transporters. Therefore, drugs that act either directl...

Teachers were asked to identify and rank 10 preferred stimuli for 9 toddlers, and a hierarchy of preference for these items was determined via a direct preference assessment. The reinforcing efficacy of the most highly preferred items identified by each method was evaluated concurrently in a reinforcer assessment. The reinforcer assessment showed that all stimuli identified as highly preferred ...

Nicotine self-administration in rats is the most widely used animal model of tobacco dependence. There is increasing evidence, however, that non-nicotinic constituents in smoke contribute to addiction and that different tobacco products contain varying levels of these constituents. The present study firstly sought to compare self-administration of pure nicotine to tobacco particulate matter (TP...

Intermittent, extended access to preferred diets increases their intake. However, the effects of such access on the acceptance and reinforcing efficacy of otherwise satisfying alternatives is less known. To investigate the role of nonnutritional contributions to the hypophagia that follows removal of preferred food, male Wistar rats were fed a chow diet (Chow A/I), preferred to their regular ch...

Saccadic endpoint variability is often viewed as the outcome of neural noise occurring during sensorimotor processing. However, part of this variability might result from operant learning. We tested this hypothesis by reinforcing dispersions of saccadic amplitude distributions, while maintaining constant their medians. In a first experiment we reinforced the least frequent saccadic amplitudes t...

There is convincing evidence that targeting self-efficacy is an effective means of increasing physical activity. However, evidence concerning which are the most effective techniques for changing self-efficacy and thereby physical activity is lacking. The present review aims to estimate the association between specific intervention techniques used in physical activity interventions and change ob...

weight to a finding published a decade ago by the group at St Jude Children’s Research Hospital. That finding stated that patients with low TPMT activity receiving 6-MP in combination with radiotherapy have increased risk of SMNs.6 The paper leaves many questions unanswered. Whether this association is caused by 6-MP therapy alone or whether high-dose MTX given along with 6-MP in maintenance co...