PURPOSE Misfolding mutations in rod opsin are a major cause of the inherited blindness retinitis pigmentosa. Therefore, understanding the role of molecular chaperones in facilitating rod opsin biogenesis and the response to mutant rod opsin is important for retinal disease and fundamental retinal cell biology. A recent report has shown that Drosophila rhodopsin Rh1 requires calnexin (Cnx) for i...

Purpose To introduce a new model of telescopic intramedullary rod (TIR), evaluate its effects on treating patients presenting with moderate and severe osteogenesis imperfecta (OI) and to compare the findings with those of other telescopic rods. Methods A total of 21 patients (nine girls and 12 boys; mean age at first operation, 6.6 years, 1.52 to 13.18) who underwent 52 femoral operations wer...

Improvement of ferroelectric property by LaNiO3 (LNO) electrode on superlattice films was shown in this study. High quality asymmetric multiferroic 5 at% La-doped BiFeO3 (BFO) and paraelectric SrTiO3 confirmed by clear main feature and satellite features around (0 0 2) STO substrate Bragg peak shown in (0 0 2) radial scan spectrum. The results of in-pane crystal truncation rod (CTR) spectrum an...

Albeit ultrahigh in energy density, the Li-O2 battery technology still suffers from the high overpotential of Li2O2 oxidation upon charging and the low cyclability. In the present work, we use Pt2Ru/C as the oxygen-electrode catalyst and study how it improves the cell performance and changes the reaction mechanism, as compared with a carbon electrode. Multiple methods, including X-ray diffracti...

PURPOSE Determine the impact of rod photoreceptor-specific expression of Cre recombinase on the kinetics of phototransduction in the mouse eye and identify changes in gene expression that underlie any observed phenotypic differences. METHODS Transretinal ERG and single-cell suction electrode recordings were used to measure the kinetics of phototransduction in a mouse line exhibiting rod photo...

Current understanding suggests that mammalian rod photoreceptors connect only to an ON-type bipolar cell. This rod-specific bipolar cell excites the All amacrine cell, which makes connections to cone-specific bipolar cells of both ON and OFF type; these, in turn, synapse with ganglion cells. Recent work on rabbit retina has shown that rod signals can also reach ganglion cells without passing th...

The light-induced proton uptake of rod outer segment disc membranes has been investigated in the absence and presence of G-protein. Proton uptake was measured as the alkalisation of the suspending medium using a pH electrode and/or the indicator dye bromocresol purple. It was found that besides the known proton uptake of photolysed rhodopsin additional uptake of one proton accompanies formation...

The two main electrode techniques for fullerenes production; the direct arc technique and the resistive heating of graphite rod were employed in this work. One of the electrodes was resistively heated to high temperature and subjected to arc discharge along its length by the second graphite rod. Fullerenes solid were extracted from carbon soot samples collected from an installed arc discharge s...

A minimally invasive technique is described for recording the a-wave of the human ERG and extracting the parameters of transduction in the rod and cone photoreceptors. A corneal DTL fibre electrode is used, but the pupil is not dilated and the cornea is not anaesthetized. Although the amplitude of the signal collected by the DTL electrode varies from session to session, this is not a problem, a...