CD22ΔE12 has emerged as a driver lesion in the pathogenesis of pediatric B-lineage acute lymphoblastic leukemia (ALL) and a new molecular target for RNA therapeutics. Here we report a 43-gene CD22ΔE12 signature transcriptome that shows a striking representation in primary human leukemia cells from patients with relapsed BPL. Our data uniquely indicate that CD22ΔE12 is a candidate driver lesion ...

Spliceosome-mediated RNA trans-splicing has become an emergent tool for the repair of mutated pre-mRNAs in the treatment of genetic diseases. RNA trans-splicing molecules (RTMs) are designed to induce a specific trans-splicing reaction via a binding domain for a respective target pre-mRNA region. A previously established reporter-based screening system allows us to analyze the impact of various...

BACKGROUND This study was designed to determine whether physician-led remote telemedical management (RTM) compared with usual care would result in reduced mortality in ambulatory patients with chronic heart failure (HF). METHODS AND RESULTS We enrolled 710 stable chronic HF patients in New York Heart Association functional class II or III with a left ventricular ejection fraction ≤35% and a h...

SRTM/DTM2006.0 residual terrain model data to improve quasigeoid computations in mountainous areas devoid of gravity data, Journal of Geodesy 84(9): 557-567. Abstract: A global geopotential model, like EGM2008, is not capable of representing the high-frequency components of Earth's gravity field. This is known as the omission error. In mountainous terrain, omission errors in EGM2008, even when ...

The ocean algorithm is based on the physical Radiative Transfer Model (RTM) described in Wentz and Meissner [2000]. The RTM consists of an atmospheric absorption model for water vapor, oxygen and liquid cloud water and a sea surface emissivity model that parameterizes the emissivity as function of sea surface temperature, sea surface salinity, sea surface wind speed and direction. The details o...

We use referential translation machines (RTM) for quality estimation of translation outputs. RTMs are a computational model for identifying the translation acts between any two data sets with respect to interpretants selected in the same domain, which are effective when making monolingual and bilingual similarity judgments. RTMs achieve top performance in automatic, accurate, and language indep...

BACKGROUND Regression to the mean (RTM) is a statistical phenomenon that can make natural variation in repeated data look like real change. It happens when unusually large or small measurements tend to be followed by measurements that are closer to the mean. METHODS We give some examples of the phenomenon, and discuss methods to overcome it at the design and analysis stages of a study. RESU...

This study demonstrates that in mountainous areas the use of residual terrain model (RTM) data significantly improves the accuracy of vertical deflections obtained from high-degree spherical harmonic synthesis. The new Earth gravitational model EGM2008 is used to compute vertical deflections up to a spherical harmonic degree of 2160. RTM data can be constructed as difference between high-resolu...

The recycling of thermoset-based composites is challenging. replacement thermosetting resins with thermoplastics an initial step to address this issue, together the use green reinforcements. Owing recent development low-viscosity thermoplastic resins, it possible produce matrix using resin transfer molding (RTM) technique, which was originally conceived for production composites. These are base...