نتایج جستجو برای: schistosomicidal drugs

تعداد نتایج: 224288  

پایان نامه :دانشگاه آزاد اسلامی - دانشگاه آزاد اسلامی واحد تهران مرکزی - دانشکده علوم پایه 1389

nowadays, the development of anti cancer drugs is an important subject in pharmacology. bisphosphonates (b.p) are a great choice for design and production of the types of drugs which not only could perform as anti cancer agents but also could inhibit the function of acetyl cholinesterase (ache). ache hydrolyzes the acetylcholine (which is a neurotransmitter in nervous system) using the oh in i...

Journal: :Antimicrobial agents and chemotherapy 2014
Edna de Farias Santiago Sheilla Andrade de Oliveira Gevânio Bezerra de Oliveira Filho Diogo Rodrigo Magalhaes Moreira Paulo André Teixeira Gomes Anekécia Lauro da Silva Andréia Ferreira de Barros Aline Caroline da Silva Thiago André Ramos Dos Santos Valéria Rêgo Alves Pereira Gabriel Gazzoni Araújo Gonçalves Fábio André Brayner Luiz Carlos Alves Almir Gonçalves Wanderley Ana Cristina Lima Leite

Schistosomiasis is a chronic and debilitating disease caused by a trematode of the genus Schistosoma and affects over 207 million people. Chemotherapy is the only immediate recourse for minimizing the prevalence of this disease and involves predominately the administration of a single drug, praziquantel (PZQ). Although PZQ has proven efficacy, there is a recognized need to develop new drugs as ...

Journal: :Infection and immunity 2003
Afzal A Siddiqui Troy Phillips Hugues Charest Ron B Podesta Martha L Quinlin Justin R Pinkston Jenny D Lloyd Michelle Paz Rachael M Villalovos Janet Pompa

Considerable morbidity and mortality result from schistosomiasis, an affliction affecting an estimated 200 million people. Although schistosomicidal drugs and other control measures (including public hygiene and snail control) exist, the advent of an efficacious vaccine remains the most potentially powerful means for controlling this disease. We have targeted a vaccine candidate (large subunit ...

Journal: :Molecules 2014
Marcos P N Silva George L S Oliveira Rusbene B F de Carvalho Damião P de Sousa Rivelilson M Freitas Pedro L S Pinto Josué de Moraes

Schistosomiasis is a neglected tropical disease that affects hundreds of millions of people worldwide. Since the treatment of this disease currently relies on a single drug, praziquantel, new and safe schistosomicidal agents are urgently required. Nerolidol, a sesquiterpene present in the essential oils of several plants, is found in many foods and was approved by the U.S. Food and Drug Adminis...

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