This study used the peptides omega-conotoxin GVIA, omega-agatoxin IVA and omega-conotoxin MVIIC, singly and in combination, to investigate the relative involvement of N-, P- and Q-type voltage-operated calcium channels in the control of striatal dopamine release. Electrically stimulated dopamine release was measured by fast cyclic voltammetry at carbon fibre microelectrodes in rat striatal slic...

PURPOSE To test the hypothesis that a moderate electrical stimulation of the cervical sympathetic nerves in rabbits can increase intraocular pressure (IOP). METHODS Electrical stimulations of the cervical sympathetic nerves were performed in anesthetized and conscious rabbits. Intraocular pressure, pupil size, and concentrations of aqueous humor components were monitored. RESULTS In urethan...

The aim of this study was to assess whether neurones of area V6A, a part of Brodmann's area 19, are modulated by passive somatosensory stimulations. Extracellular activity was recorded in four awake while passive tactile stimulations of the skin and passive rotations of the joints were performed in complete darkness and under eye movement control. Out of 240 V6A units, 78 (32%) were modulated b...

In four dogs instrumental defensive conditioned reflexes to direct electrical stimulation of the hippocampus were elaborated. After reaching 60 percent CR performance, unreinforced stimulations of several limbic structures were given to test generalization. Positive generalization was more frequent than negative one. The generalization effect changed considerably in the course of further condit...

Clinical and research efforts have focused on promoting functional recovery after stroke. Brain stimulation strategies are particularly promising because they allow direct manipulation of the target area's excitability. However, elucidating the cell type and mechanisms mediating recovery has been difficult because existing stimulation techniques nonspecifically target all cell types near the st...

Introduction: Previous studies have been shown that low frequency stimulation (LFS) has an inhibitory effect on kindling acquisition. However, the mechanism of this effect has not been completely determined. In the present study, the effect of LFS of the perforant path on seizures induced by rapid perforant path kindling was investigated. Methods: Animals were kindled by electrical stimulatio...

In this study, effects of Buthus eupeus venom on chick biventer cervices nerve-muscle preparation were investigated by twitch tension method. The venom, at 1.3 ?g/ml, increased contractile responses in indirect stimulations. These effects were milder in direct muscle stimulations. It also caused significant enhancement in postjunctional sensitivity as assessed by responses to exogenous acetylch...

Objective: The hypotheses related to the fact of epileptic mechanisms are mainly based on excitation-inhibition imbalance in central nervous system. GAERS (Genetic Absence Epilepsy Rats from Strasbourg) is a well-known animal model absence epilepsy, and frequently used experimental studies. In present study, we aimed examine possible morphological gamma-aminobutyric acid (GABA) density changes ...