background: the present study was conducted in order to evaluate the effects of bilateral uterine artery ligation (bual) on the ovarian follicular fate, and alterations in carbohydrate, lipid, lipase and serum levels of f9sh, lh, prolactin, estrogen and progesterone. methods: twenty-four mature female rabbits divided into two test and control-sham groups. the animals underwent ovariohystrectomy...

We have previously shown that changes in estrogen-hepatocyte interaction occur during liver regeneration. Following 70% hepatectomy, estrogen levels in the blood were elevated, the number of estrogen receptors in the liver was increased and there was an active translocation of estrogen receptors from the cytosol to the nucleus. The injection of tamoxifen, an estrogen antagonist, inhibits hepato...

CONTENTS Chapter 1 General introduction 7 Chapter 2 Bone mineral density as a marker of cumulative endogenous estrogen 19 exposure: relationship to background genetic risk of psychotic disorder Chapter 3 Testing the estrogen hypothesis of schizophrenia: associations between 37 cumulative estrogen exposure and cerebral structural measures Chapter 4 Bone mineral density as a marker of cumulative ...

Oral squamous cell carcinoma is an important malignancy of epithelial origin with high rate of morbidity and mortality. While tobacco and alcohol are the primary risk factors; other factors such as microorganisms, chronic irritation and sex hormones along with underlying genetic factors may also contribute to its pathogenesis. The role of sex hormones like estrogen, progesterone and testosteron...

to evaluate the effectiveness of conjugated estrogen (premarin) and progesterone in twenty-one postmenopausal women who had been menopause one year, we tested during a 6-month period the serum lipoprotein levels in subjects who offered by premarin in dosage of 0.625 milligram for days 1 to 25 and oral medroxy progestrone acetste for days 15 to 25 of a 30-day cycle. twenty-one subjects completed...

The presence of estrogen receptor beta and aromatase in the germ cell has highlighted the physiological role of the traditionally female hormone, estrogen, in spermatogenesis. Estrogen receptor alpha knockouts and aromatase knockouts have further accentuated the role of estrogen in germ cell maturation. To delineate the direct action of estrogen in the seminiferous epithelium, we studied the ef...

Introduction: PCOS is an important reproductive and endocrine disorder in women in the reproductive age. Present reports indicate that Vitex agnus-castus acts through hypothalamus-pituitary axis. This study was carried out to evaluate the effects of Vitex fruit hydroalcoholic extract on the alteration of sex hormones in a PCOS animal model. Methods: Following 14 days of monitoring of estrous...

After once-daily oral dosing in ovariectomized rats, raloxifene (LY139481) hydrochloride produced dose- and time-dependent reductions in serum cholesterol and high-density lipoprotein-cholesterol. Paired-feeding studies demonstrated that effects of raloxifene on serum lipids were not secondary to effects on food consumption. Maximal reductions in serum cholesterol occurred within 4 days of ralo...

Trans-3,4,5-trihydroxystilbene (resveratrol), a polyphenolic compound found in juice and wine from dark-skinned grape cultivars, was recently shown to bind to estrogen receptors in vitro, where it activated transcription of estrogen-responsive reporter genes. The purpose of this 6-day study in weanling rats was to determine the dose response (1, 4, 10, 40, and 100 microg/day) effects of orally ...

Cell proliferation kinetics during growth of an estrogen recep tor-positive human breast carcinoma cell line, T-47D, was de fined, and some factors which modify its response to tamoxifen were investigated in vitro. T-47D cells were estrogen responsive when grown in charcoal-stripped fetal calf serum, but the addition of 17/3-estradiol did not fully restore the growth rate to that observed in th...