Skin cancer is one of the most common cancers. Melanoma accounts for less than 2% of skin cancer cases but causes a large majority of skin cancer deaths. Early detection of malignant melanoma remains the key factor in saving lives. However, the melanoma diagnosis is still clinically challenging. Here, we developed a confocal photothermal microscope for noninvasive, label-free, three-dimensional...

Forsythia fructus has been shown to have antioxidative, anti-inflammatory, antibacterial, antiaging and whitening effects. Hoechunyangkyeok-san (Forsythia viridissima-prescription) is a traditional herbal medicine, which has been clinically used for treating febrile and inflammatory disorders. This work was carried out to investigate the skin whitening effects of Forsythia viridissima-prescript...

Attempts to understand the changes in the structure and physiology of human skin abnormalities by non-invasive optical imaging are aided by spectroscopic methods that quantify, at the molecular level, variations in tissue oxygenation and melanin distribution. However, current commercial and research systems to map hemoglobin and melanin do not correlate well with pathology for pigmented lesions...

The purpose of this study is to characterize the effects of KHG26792 (3-(naphthalen-2-yl(propoxy) methyl)azetidine hydrochloride), a potential skin whitening agent, on melanin synthesis and identify the underlying mechanism of action. Our data showed that KHG26792 significantly reduced melanin synthesis in a dose-dependent manner. Additionally, KHG26792 downregulated microphthalmia-associated t...

In this study, the inhibitory effect of corn silk on melanin production was evaluated. This study was performed to investigate the inhibitory effect of corn silk on melanin production in Melan-A cells by measuring melanin production and protein expression. The corn silk extract applied on Melan-A cells at a concentration of 100 ppm decreased melanin production by 37.2% without cytotoxicity. Thi...

Melanin the natural color in our skin is synthesized by melanocytes. The distribution pattern in the surrounding keratinocytes and the nature of the formed melanin determine the actual color of our skin. Melanin forms through a series of oxidative reactions involving the amino acid tyrosine in the presence of the enzyme tyrosinase. Skin whitening agents often inhibit the activity of tyrosinase,...

INTRODUCTION Punica granatum is apotent source of polyphenolic compounds with strong free radicals scavenging activity. The skin lightening effects of Punica granatum are assumed due to ellagic acid which acts by chelating copper at the active site of tyrosinase. AIM To explore a topical microemulsion (O/W) of pomegranate (Punica granatum) extract for its control on skin erythema and melanin....

Background: Continual exposure to the sun's ultraviolet radiation damages skin. Freckles are little brown patches that develop on skin after repeated sun exposure. Terminalia chebula and Cucumber Sativus extracts-infused water in oil (W/O) emulsion is created, has anti-freckle emollient effect. Methodology: Base with no extract formulation containing three different concentrations 4% of Chebula...

The aim of this work was to study skin parameters like melanin, erythema, skin hydration, and sebum score of six body sites namely volar forearm, cheek, chin, forehead, neck and post auricular skin of Asian (Indian) population with different skin colour and types to depict the formulation to be used for taking care. Initially skin colour of various volunteers was assessed by the reference of co...