The canine mammary tumor system is receiving increas ing attention as a model system for drug testing and for experimental study of basic mammary biology. In order to contribute to this model system, the hormone sensitivity of three types of canine preneoplastic lesions was identified morphologically on the basis of in vitro responses of organcultured expiants to various hormone supplements. Dy...

This study was conducted to determine the effect of daily recombinant porcine somatotropin (rpST) injection (0 or 120 pg/kg BW) and dietary CP level of the feed (14 or 26% CP) on pancreatic characteristics of growing pigs. Daily injection of rpST did not affect pancreatic weight ( P = .885) but did decrease pancreatic amylase content ( P = .005). The ratios of amy1ase:protein and amy1ase:trypsi...

Thirty-seven pigs with an initial live weight of 60 kg were used to investigate the effects of daily exogenous porcine somatotropin (pST) administration at two dose levels (0 and 100 micrograms.kg-1.d-1) for a 31-d period on muscle fiber characteristics and meat tenderness of boars, gilts and barrows. Excipient boars and gilts had more alpha W and fewer alpha R fibers than did those receiving p...

General debility and loss of body weight is commonly associated with diabetes meIlitus. This seems to be related to the deficiency of insulin, responsible for the inhibition of oxidative phosphorylation (10) and decreased synthesis of proteins (17) which in turn reduces the elaboration of anterior pituitary trophic hormones (9). Moreover the growth stimulating and nitrogen retaining effects of ...

The protective effect of bovine somatotropin (bST) during experimental Streptococcus uberis mastitis in cows was studied. The left quarters of 10 cows were infected with 500 cfu of S. uberis O140J. Five cows were subcutaneously treated with 500 mg of recombinant bST 7 d before and after infection, and 5 control cows received the excipient. In the treated cows, total milk production significantl...

Forty-eight Yorkshire cross pigs of three stress susceptibility classes (stress positive, stress-carrier, and stress negative) were injected daily with porcine somatotropin (pST; 4 mg/d) or placebo. Each pig was injected in the neck once daily until taken off test, starting when the pigs weighed 59 kg. Porcine somatotropin treatment was terminated at weekly intervals as individual pigs reached ...

This manuscript presents the results of a review of the effects of recombinant bovine somatotropin (rBST) on milk production, milk composition, dry matter intake, and body condition score that was carried out by an expert panel established by the Canadian Veterinary Medical Association (CVMA). The panel was established by the CVMA in response to a request from Health Canada in 1998 and their re...